Show simple item record

dc.contributor.authorOperario, DJ
dc.contributor.authorPlatts-Mills, JA
dc.contributor.authorNadan, S
dc.contributor.authorPage, N
dc.contributor.authorSeheri, M
dc.contributor.authorMphahlele, J
dc.contributor.authorPraharaj, I
dc.contributor.authorKang, G
dc.contributor.authorAraujo, IT
dc.contributor.authorLeite, JPG
dc.contributor.authorCowley, D
dc.contributor.authorThomas, S
dc.contributor.authorKirkwood, CD
dc.contributor.authorDennis, F
dc.contributor.authorArmah, G
dc.contributor.authorMwenda, JM
dc.contributor.authorWijesinghe, PR
dc.contributor.authorRey, G
dc.contributor.authorGrabovac, V
dc.contributor.authorBerejena, C
dc.contributor.authorSimwaka, CJ
dc.contributor.authorUwimana, J
dc.contributor.authorSherchand, JB
dc.contributor.authorThu, HM
dc.contributor.authorGalagoda, G
dc.contributor.authorBonkoungou, IJO
dc.contributor.authorJagne, S
dc.contributor.authorTsolenyanu, E
dc.contributor.authorDiop, A
dc.contributor.authorEnweronu-Laryea, C
dc.contributor.authorBorbor, S-A
dc.contributor.authorLiu, J
dc.contributor.authorMcMurry, T
dc.contributor.authorLopman, B
dc.contributor.authorParashar, U
dc.contributor.authorGentsch, J
dc.contributor.authorSteele, AD
dc.contributor.authorCohen, A
dc.contributor.authorSerhan, F
dc.contributor.authorHoupt, ER
dc.date.accessioned2020-12-17T03:34:09Z
dc.date.available2020-12-17T03:34:09Z
dc.date.issued2017-07-15
dc.identifierpii: 3882676
dc.identifier.citationOperario, D. J., Platts-Mills, J. A., Nadan, S., Page, N., Seheri, M., Mphahlele, J., Praharaj, I., Kang, G., Araujo, I. T., Leite, J. P. G., Cowley, D., Thomas, S., Kirkwood, C. D., Dennis, F., Armah, G., Mwenda, J. M., Wijesinghe, P. R., Rey, G., Grabovac, V. ,... Houpt, E. R. (2017). Etiology of Severe Acute Watery Diarrhea in Children in the Global Rotavirus Surveillance Network Using Quantitative Polymerase Chain Reaction. JOURNAL OF INFECTIOUS DISEASES, 216 (2), pp.220-227. https://doi.org/10.1093/infdis/jix294.
dc.identifier.issn0022-1899
dc.identifier.urihttp://hdl.handle.net/11343/254938
dc.description.abstractBackground: The etiology of acute watery diarrhea remains poorly characterized, particularly after rotavirus vaccine introduction. Methods: We performed quantitative polymerase chain reaction for multiple enteropathogens on 878 acute watery diarrheal stools sampled from 14643 episodes captured by surveillance of children <5 years of age during 2013-2014 from 16 countries. We used previously developed models of the association between pathogen quantity and diarrhea to calculate pathogen-specific weighted attributable fractions (AFs). Results: Rotavirus remained the leading etiology (overall weighted AF, 40.3% [95% confidence interval {CI}, 37.6%-44.3%]), though the AF was substantially lower in the Americas (AF, 12.2 [95% CI, 8.9-15.6]), based on samples from a country with universal rotavirus vaccination. Norovirus GII (AF, 6.2 [95% CI, 2.8-9.2]), Cryptosporidium (AF, 5.8 [95% CI, 4.0-7.6]), Shigella (AF, 4.7 [95% CI, 2.8-6.9]), heat-stable enterotoxin-producing Escherichia coli (ST-ETEC) (AF, 4.2 [95% CI, 2.0-6.1]), and adenovirus 40/41 (AF, 4.2 [95% CI, 2.9-5.5]) were also important. In the Africa Region, the rotavirus AF declined from 54.8% (95% CI, 48.3%-61.5%) in rotavirus vaccine age-ineligible children to 20.0% (95% CI, 12.4%-30.4%) in age-eligible children. Conclusions: Rotavirus remained the leading etiology of acute watery diarrhea despite a clear impact of rotavirus vaccine introduction. Norovirus GII, Cryptosporidium, Shigella, ST-ETEC, and adenovirus 40/41 were also important. Prospective surveillance can help identify priorities for further reducing the burden of diarrhea.
dc.languageEnglish
dc.publisherOXFORD UNIV PRESS INC
dc.titleEtiology of Severe Acute Watery Diarrhea in Children in the Global Rotavirus Surveillance Network Using Quantitative Polymerase Chain Reaction
dc.typeJournal Article
dc.identifier.doi10.1093/infdis/jix294
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.source.titleJournal of Infectious Diseases
melbourne.source.volume216
melbourne.source.issue2
melbourne.source.pages220-227
dc.rights.licenseCC BY
melbourne.elementsid1229792
melbourne.contributor.authorKirkwood, Carl
melbourne.contributor.authorCowley, Daniel
dc.identifier.eissn1537-6613
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record