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    Changes in parahippocampal white matter integrity in amnestic mild cognitive impairment: a diffusion tensor imaging study.

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    Author
    Rogalski, EJ; Murphy, CM; deToledo-Morrell, L; Shah, RC; Moseley, ME; Bammer, R; Stebbins, GT
    Date
    2009
    Source Title
    Behavioural Neurology: an international journal on the relationship between disordered human behavior and underlying biological mechanisms
    Publisher
    Hindawi Limited
    University of Melbourne Author/s
    Bammer, Roland; BAMMER, ROLAND
    Affiliation
    Medicine and Radiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Rogalski, E. J., Murphy, C. M., deToledo-Morrell, L., Shah, R. C., Moseley, M. E., Bammer, R. & Stebbins, G. T. (2009). Changes in parahippocampal white matter integrity in amnestic mild cognitive impairment: a diffusion tensor imaging study.. Behav Neurol, 21 (1), pp.51-61. https://doi.org/10.3233/BEN-2009-0235.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254949
    DOI
    10.3233/BEN-2009-0235
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819387
    Abstract
    In the present study, changes in the parahippocampal white matter (PWM), in the region that includes the perforant path, were investigated, in vivo, in 14 individuals with amnestic mild cognitive impairment (aMCI) compared to 14 elderly controls with no cognitive impairment (NCI). For this purpose, (1) volumetry; (2) diffusion tensor imaging (DTI) derived measures of mean diffusivity (MD) and fractional anisotropy (FA); and (3) tractography were used. In addition, regression models were utilized to examine the association of PWM measurements with memory decline. The results from this study confirm previous findings in our laboratory and others, showing that compared to controls, individuals with aMCI have PWM volume loss. In addition to volume reduction, participants with aMCI demonstrated a significant increase in MD, but no difference in FA, both in the PWM region and in fibers modeled to pass through the PWM region. Further, the DTI metric of MD was associated with declarative memory performance, suggesting it may be a sensitive marker for memory dysfunction. These results indicate that there is general tissue loss and degradation (decreased volume; increased MD) in individuals with aMCI compared to older people with normal cognitive function. However, the microstructural organization of remaining fibers, as determined by measures of anisotropic diffusion, is not significantly different from that of controls.

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