Modelling Cooperative Tumorigenesis in Drosophila

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Author
Richardson, HE; Portela, MDate
2018-01-01Source Title
BioMed Research InternationalPublisher
HINDAWI LTDUniversity of Melbourne Author/s
Richardson, HelenaAffiliation
Anatomy and NeuroscienceMetadata
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Journal ArticleCitations
Richardson, H. E. & Portela, M. (2018). Modelling Cooperative Tumorigenesis in Drosophila. BIOMED RESEARCH INTERNATIONAL, 2018, https://doi.org/10.1155/2018/4258387.Access Status
Open AccessAbstract
The development of human metastatic cancer is a multistep process, involving the acquisition of several genetic mutations, tumour heterogeneity, and interactions with the surrounding microenvironment. Due to the complexity of cancer development in mammals, simpler model organisms, such as the vinegar fly, Drosophila melanogaster, are being utilized to provide novel insights into the molecular mechanisms involved. In this review, we highlight recent advances in modelling tumorigenesis using the Drosophila model, focusing on the cooperation of oncogenes or tumour suppressors, and the interaction of mutant cells with the surrounding tissue in epithelial tumour initiation and progression.
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