Modelling Cooperative Tumorigenesis in Drosophila
AuthorRichardson, HE; Portela, M
Source TitleBioMed Research International
University of Melbourne Author/sRichardson, Helena
AffiliationAnatomy and Neuroscience
Document TypeJournal Article
CitationsRichardson, H. E. & Portela, M. (2018). Modelling Cooperative Tumorigenesis in Drosophila. BIOMED RESEARCH INTERNATIONAL, 2018, https://doi.org/10.1155/2018/4258387.
Access StatusOpen Access
The development of human metastatic cancer is a multistep process, involving the acquisition of several genetic mutations, tumour heterogeneity, and interactions with the surrounding microenvironment. Due to the complexity of cancer development in mammals, simpler model organisms, such as the vinegar fly, Drosophila melanogaster, are being utilized to provide novel insights into the molecular mechanisms involved. In this review, we highlight recent advances in modelling tumorigenesis using the Drosophila model, focusing on the cooperation of oncogenes or tumour suppressors, and the interaction of mutant cells with the surrounding tissue in epithelial tumour initiation and progression.
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