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    Modelling Cooperative Tumorigenesis in Drosophila

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    Author
    Richardson, HE; Portela, M
    Date
    2018-01-01
    Source Title
    BioMed Research International
    Publisher
    HINDAWI LTD
    University of Melbourne Author/s
    Richardson, Helena
    Affiliation
    Anatomy and Neuroscience
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Richardson, H. E. & Portela, M. (2018). Modelling Cooperative Tumorigenesis in Drosophila. BIOMED RESEARCH INTERNATIONAL, 2018, https://doi.org/10.1155/2018/4258387.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/254969
    DOI
    10.1155/2018/4258387
    Abstract
    The development of human metastatic cancer is a multistep process, involving the acquisition of several genetic mutations, tumour heterogeneity, and interactions with the surrounding microenvironment. Due to the complexity of cancer development in mammals, simpler model organisms, such as the vinegar fly, Drosophila melanogaster, are being utilized to provide novel insights into the molecular mechanisms involved. In this review, we highlight recent advances in modelling tumorigenesis using the Drosophila model, focusing on the cooperation of oncogenes or tumour suppressors, and the interaction of mutant cells with the surrounding tissue in epithelial tumour initiation and progression.

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