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dc.contributor.authorYawno, T
dc.contributor.authorMiller, SL
dc.contributor.authorBennet, L
dc.contributor.authorWong, F
dc.contributor.authorHirst, JJ
dc.contributor.authorFahey, M
dc.contributor.authorWalker, DW
dc.date.accessioned2020-12-17T03:41:11Z
dc.date.available2020-12-17T03:41:11Z
dc.date.issued2017-08-22
dc.identifier.citationYawno, T., Miller, S. L., Bennet, L., Wong, F., Hirst, J. J., Fahey, M. & Walker, D. W. (2017). Ganaxolone : A New Treatment for Neonatal Seizures. FRONTIERS IN CELLULAR NEUROSCIENCE, 11, https://doi.org/10.3389/fncel.2017.00246.
dc.identifier.issn1662-5102
dc.identifier.urihttp://hdl.handle.net/11343/254988
dc.description.abstractNeonatal seizures are amongst the most common neurologic conditions managed by a neonatal care service. Seizures can exacerbate existing brain injury, induce "de novo" injury, and are associated with neurodevelopmental disabilities in post-neonatal life. In this mini-review, we present evidence in support of the use of ganaxolone, a GABAA agonist neurosteroid, as a novel neonatal therapy. We discuss evidence that ganaxolone can provide both seizure control and neuroprotection with a high safety profile when administered early following birth-related hypoxia, and show evidence that it is likely to prevent or reduce the incidence of the enduring disabilities associated with preterm birth, cerebral palsy, and epilepsy. We suggest that ganaxolone is an ideal anti-seizure treatment because it can be safely used prospectively, with minimal or no adverse effects on the neonatal brain.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleGanaxolone : A New Treatment for Neonatal Seizures
dc.typeJournal Article
dc.identifier.doi10.3389/fncel.2017.00246
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleFrontiers in Cellular Neuroscience
melbourne.source.volume11
dc.rights.licenseCC BY
melbourne.elementsid1326293
melbourne.contributor.authorFahey, Michael
dc.identifier.eissn1662-5102
melbourne.accessrightsOpen Access


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