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dc.contributor.authorMladenova, D
dc.contributor.authorBarry, G
dc.contributor.authorKonen, LM
dc.contributor.authorPineda, SS
dc.contributor.authorGuennewig, B
dc.contributor.authorAvesson, L
dc.contributor.authorZinn, R
dc.contributor.authorSchonrock, N
dc.contributor.authorBitar, M
dc.contributor.authorJonkhout, N
dc.contributor.authorCrumlish, L
dc.contributor.authorKaczorowski, DC
dc.contributor.authorGong, A
dc.contributor.authorPinese, M
dc.contributor.authorFranco, GR
dc.contributor.authorWalkley, CR
dc.contributor.authorVissel, B
dc.contributor.authorMattick, JS
dc.date.accessioned2020-12-17T03:42:11Z
dc.date.available2020-12-17T03:42:11Z
dc.date.issued2018-04-13
dc.identifier.citationMladenova, D., Barry, G., Konen, L. M., Pineda, S. S., Guennewig, B., Avesson, L., Zinn, R., Schonrock, N., Bitar, M., Jonkhout, N., Crumlish, L., Kaczorowski, D. C., Gong, A., Pinese, M., Franco, G. R., Walkley, C. R., Vissel, B. & Mattick, J. S. (2018). Adar3 Is Involved in Learning and Memory in Mice. FRONTIERS IN NEUROSCIENCE, 12 (APR), https://doi.org/10.3389/fnins.2018.00243.
dc.identifier.issn1662-453X
dc.identifier.urihttp://hdl.handle.net/11343/254995
dc.description.abstractThe amount of regulatory RNA encoded in the genome and the extent of RNA editing by the post-transcriptional deamination of adenosine to inosine (A-I) have increased with developmental complexity and may be an important factor in the cognitive evolution of animals. The newest member of the A-I editing family of ADAR proteins, the vertebrate-specific ADAR3, is highly expressed in the brain, but its functional significance is unknown. In vitro studies have suggested that ADAR3 acts as a negative regulator of A-I RNA editing but the scope and underlying mechanisms are also unknown. Meta-analysis of published data indicates that mouse Adar3 expression is highest in the hippocampus, thalamus, amygdala, and olfactory region. Consistent with this, we show that mice lacking exon 3 of Adar3 (which encodes two double stranded RNA binding domains) have increased levels of anxiety and deficits in hippocampus-dependent short- and long-term memory formation. RNA sequencing revealed a dysregulation of genes involved in synaptic function in the hippocampi of Adar3-deficient mice. We also show that ADAR3 transiently translocates from the cytoplasm to the nucleus upon KCl-mediated activation in SH-SY5Y cells. These results indicate that ADAR3 contributes to cognitive processes in mammals.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleAdar3 Is Involved in Learning and Memory in Mice
dc.typeJournal Article
dc.identifier.doi10.3389/fnins.2018.00243
melbourne.affiliation.departmentMedicine (St Vincent's)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleFrontiers in Neuroscience
melbourne.source.volume12
melbourne.source.issueAPR
dc.rights.licenseCC BY
melbourne.elementsid1326625
melbourne.contributor.authorWalkley, Carl
dc.identifier.eissn1662-453X
melbourne.accessrightsOpen Access


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