Consensus guidelines for the use and interpretation of angiogenesis assays

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    Author
    Nowak-Sliwinska, P; Alitalo, K; Allen, E; Anisimov, A; Aplin, AC; Auerbach, R; Augustin, HG; Bates, DO; van Beijnum, JR; Bender, RHF; ...
    Date
    2018-08-01
    Source Title
    Angiogenesis
    Publisher
    SPRINGER
    University of Melbourne Author/s
    Stacker, Steven
    Affiliation
    Sir Peter MacCallum Department of Oncology
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    Document Type
    Journal Article
    Citations
    Nowak-Sliwinska, P., Alitalo, K., Allen, E., Anisimov, A., Aplin, A. C., Auerbach, R., Augustin, H. G., Bates, D. O., van Beijnum, J. R., Bender, R. H. F., Bergers, G., Bikfalvi, A., Bischoff, J., Boeck, B. C., Brooks, P. C., Bussolino, F., Cakir, B., Carmeliet, P., Castranova, D. ,... Griffioen, A. W. (2018). Consensus guidelines for the use and interpretation of angiogenesis assays. ANGIOGENESIS, 21 (3), pp.425-532. https://doi.org/10.1007/s10456-018-9613-x.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255004
    DOI
    10.1007/s10456-018-9613-x
    Abstract
    The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.

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