Consensus guidelines for the use and interpretation of angiogenesis assays

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Nowak-Sliwinska, P; Alitalo, K; Allen, E; Anisimov, A; Aplin, AC; Auerbach, R; Augustin, HG; Bates, DO; van Beijnum, JR; Bender, RHF; ...Date
2018-08-01Source Title
AngiogenesisPublisher
SPRINGERUniversity of Melbourne Author/s
Stacker, StevenAffiliation
Sir Peter MacCallum Department of OncologyMetadata
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Journal ArticleCitations
Nowak-Sliwinska, P., Alitalo, K., Allen, E., Anisimov, A., Aplin, A. C., Auerbach, R., Augustin, H. G., Bates, D. O., van Beijnum, J. R., Bender, R. H. F., Bergers, G., Bikfalvi, A., Bischoff, J., Boeck, B. C., Brooks, P. C., Bussolino, F., Cakir, B., Carmeliet, P., Castranova, D. ,... Griffioen, A. W. (2018). Consensus guidelines for the use and interpretation of angiogenesis assays. ANGIOGENESIS, 21 (3), pp.425-532. https://doi.org/10.1007/s10456-018-9613-x.Access Status
Open AccessAbstract
The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.
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