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dc.contributor.authorRežić-Mužinić, N
dc.contributor.authorMastelić, A
dc.contributor.authorBenzon, B
dc.contributor.authorMarkotić, A
dc.contributor.authorMudnić, I
dc.contributor.authorGrković, I
dc.contributor.authorGrga, M
dc.contributor.authorMilat, AM
dc.contributor.authorKljučević, N
dc.contributor.authorBoban, M
dc.date.accessioned2020-12-17T03:44:11Z
dc.date.available2020-12-17T03:44:11Z
dc.date.issued2018
dc.identifierpii: PONE-D-17-28680
dc.identifier.citationRežić-Mužinić, N., Mastelić, A., Benzon, B., Markotić, A., Mudnić, I., Grković, I., Grga, M., Milat, A. M., Ključević, N. & Boban, M. (2018). Expression of adhesion molecules on granulocytes and monocytes following myocardial infarction in rats drinking white wine.. PLoS One, 13 (5), pp.e0196842-. https://doi.org/10.1371/journal.pone.0196842.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/255009
dc.description.abstractNeutrophils and monocytes through their CD15s, CD11b and CD44 adhesion molecules are implicated in the initiation and resolution of cardiac inflammation as well as in healing processes after the myocardial infarction (MI). The aim of this study was to determine the effect of white wine consumption on granulocyte and monocyte CD15s, CD11b, and CD44 expression 24h after the surgically inflicted MI. Granulocytes and monocytes were analyzed by flow cytometry, using whole blood of male Sprague-Dawley rats that consumed white wine for 4 weeks. This group was compared with water only drinking controls, sham animals (subject to surgery without myocardial infarction) and baseline group (intact animals that received no intervention prior to being sacrificed). Sham animals did not differ from baseline animals in CD11b+CD44+ percentage and CD44+ median fluorescence intensity. Wine drinking was associated with striking increase in CD44 expression on monocyte subpopulations. Its expression was three and fourfold increased on monocytes and large monocytes, respectively, relative to the water only drinking controls. Because of known role of CD44 on suppression of post-infarction inflammation, its upregulation on granulocytes and monocytes may significantly contribute to the microenvironment favourable for the cardiac regeneration.
dc.languageeng
dc.publisherPublic Library of Science (PLoS)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleExpression of adhesion molecules on granulocytes and monocytes following myocardial infarction in rats drinking white wine.
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0196842
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.source.titlePLoS One
melbourne.source.volume13
melbourne.source.issue5
melbourne.source.pagese0196842-
dc.rights.licenseCC BY
melbourne.elementsid1329598
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945017
melbourne.contributor.authorGrkovic, Ivica
dc.identifier.eissn1932-6203
melbourne.accessrightsOpen Access


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