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    Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

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    Author
    Iglesias, AI; Mishra, A; Vitart, V; Bykhovskaya, Y; Hoehn, R; Springelkamp, H; Cuellar-Partida, G; Gharahkhani, P; Bailey, JNC; Willoughby, CE; ...
    Date
    2018-05-14
    Source Title
    Nature Communications
    Publisher
    NATURE PUBLISHING GROUP
    University of Melbourne Author/s
    Wong, Tien; Mackey, David; Craig, Jamie; Hewitt, Alexander; STAFFIERI, SANDRA; Mitchell, Paul
    Affiliation
    Ophthalmology (Eye & Ear Hospital)
    Centre for Eye Research Australia (CERA)
    Medicine and Radiology
    Clinical Pathology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Iglesias, A. I., Mishra, A., Vitart, V., Bykhovskaya, Y., Hoehn, R., Springelkamp, H., Cuellar-Partida, G., Gharahkhani, P., Bailey, J. N. C., Willoughby, C. E., Li, X., Yazar, S., Nag, A., Khawaja, A. P., Polasek, O., Siscovick, D., Mitchell, P., Tham, Y. C., Haines, J. L. ,... MacGregor, S. (2018). Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. NATURE COMMUNICATIONS, 9 (1), https://doi.org/10.1038/s41467-018-03646-6.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255052
    DOI
    10.1038/s41467-018-03646-6
    Abstract
    Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, pathway analyses uncover previously unreported gene sets. Remarkably, >20% of the CCT-loci are near or within Mendelian disorder genes. These included FBN1, ADAMTS2 and TGFB2 which associate with connective tissue disorders (Marfan, Ehlers-Danlos and Loeys-Dietz syndromes), and the LUM-DCN-KERA gene complex involved in myopia, corneal dystrophies and cornea plana. Using index CCT-increasing variants, we find a significant inverse correlation in effect sizes between CCT and keratoconus (r = -0.62, P = 5.30 × 10-5) but not between CCT and primary open-angle glaucoma (r = -0.17, P = 0.2). Our findings provide evidence for shared genetic influences between CCT and keratoconus, and implicate candidate genes acting in collagen and extracellular matrix regulation.

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