The effect on melanoma risk of genes previously associated with telomere length.
AuthorIles, MM; Bishop, DT; Taylor, JC; Hayward, NK; Brossard, M; Cust, AE; Dunning, AM; Lee, JE; Moses, EK; Akslen, LA; ...
Source TitleJournal of the National Cancer Institute
PublisherOxford University Press (OUP)
University of Melbourne Author/sCUST, ANNE
AffiliationMelbourne School of Population and Global Health
Document TypeJournal Article
CitationsIles, M. M., Bishop, D. T., Taylor, J. C., Hayward, N. K., Brossard, M., Cust, A. E., Dunning, A. M., Lee, J. E., Moses, E. K., Akslen, L. A., AMFS Investigators, Andresen, P. A., Avril, M. -F., Azizi, E., Scarrà, G. B., Brown, K. M., Dębniak, T., Elder, D. E., Friedman, E. ,... GenoMEL Consortium (2014). The effect on melanoma risk of genes previously associated with telomere length.. J Natl Cancer Inst, 106 (10), pp.dju267--. https://doi.org/10.1093/jnci/dju267.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196080
Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10(-9), two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.
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