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    The effect on melanoma risk of genes previously associated with telomere length.

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    Author
    Iles, MM; Bishop, DT; Taylor, JC; Hayward, NK; Brossard, M; Cust, AE; Dunning, AM; Lee, JE; Moses, EK; Akslen, LA; ...
    Date
    2014-10
    Source Title
    Journal of the National Cancer Institute
    Publisher
    Oxford University Press (OUP)
    University of Melbourne Author/s
    CUST, ANNE
    Affiliation
    Melbourne School of Population and Global Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Iles, M. M., Bishop, D. T., Taylor, J. C., Hayward, N. K., Brossard, M., Cust, A. E., Dunning, A. M., Lee, J. E., Moses, E. K., Akslen, L. A., AMFS Investigators, Andresen, P. A., Avril, M. -F., Azizi, E., Scarrà, G. B., Brown, K. M., Dębniak, T., Elder, D. E., Friedman, E. ,... GenoMEL Consortium (2014). The effect on melanoma risk of genes previously associated with telomere length.. J Natl Cancer Inst, 106 (10), pp.dju267--. https://doi.org/10.1093/jnci/dju267.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255081
    DOI
    10.1093/jnci/dju267
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196080
    Abstract
    Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10(-9), two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.

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