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dc.contributor.authorIles, MM
dc.contributor.authorBishop, DT
dc.contributor.authorTaylor, JC
dc.contributor.authorHayward, NK
dc.contributor.authorBrossard, M
dc.contributor.authorCust, AE
dc.contributor.authorDunning, AM
dc.contributor.authorLee, JE
dc.contributor.authorMoses, EK
dc.contributor.authorAkslen, LA
dc.contributor.authorAMFS Investigators,
dc.contributor.authorAndresen, PA
dc.contributor.authorAvril, M-F
dc.contributor.authorAzizi, E
dc.contributor.authorScarrà, GB
dc.contributor.authorBrown, KM
dc.contributor.authorDębniak, T
dc.contributor.authorElder, DE
dc.contributor.authorFriedman, E
dc.contributor.authorGhiorzo, P
dc.contributor.authorGillanders, EM
dc.contributor.authorGoldstein, AM
dc.contributor.authorGruis, NA
dc.contributor.authorHansson, J
dc.contributor.authorHarland, M
dc.contributor.authorHelsing, P
dc.contributor.authorHočevar, M
dc.contributor.authorHöiom, V
dc.contributor.authorIBD investigators,
dc.contributor.authorIngvar, C
dc.contributor.authorKanetsky, PA
dc.contributor.authorLandi, MT
dc.contributor.authorLang, J
dc.contributor.authorLathrop, GM
dc.contributor.authorLubiński, J
dc.contributor.authorMackie, RM
dc.contributor.authorMartin, NG
dc.contributor.authorMolven, A
dc.contributor.authorMontgomery, GW
dc.contributor.authorNovaković, S
dc.contributor.authorOlsson, H
dc.contributor.authorPuig, S
dc.contributor.authorPuig-Butille, JA
dc.contributor.authorQMEGA and QTWIN Investigators,
dc.contributor.authorRadford-Smith, GL
dc.contributor.authorRanderson-Moor, J
dc.contributor.authorSDH Study Group,
dc.contributor.authorvan der Stoep, N
dc.contributor.authorvan Doorn, R
dc.contributor.authorWhiteman, DC
dc.contributor.authorMacGregor, S
dc.contributor.authorPooley, KA
dc.contributor.authorWard, SV
dc.contributor.authorMann, GJ
dc.contributor.authorAmos, CI
dc.contributor.authorPharoah, PDP
dc.contributor.authorDemenais, F
dc.contributor.authorLaw, MH
dc.contributor.authorNewton Bishop, JA
dc.contributor.authorBarrett, JH
dc.contributor.authorGenoMEL Consortium,
dc.date.accessioned2020-12-17T03:54:15Z
dc.date.available2020-12-17T03:54:15Z
dc.date.issued2014-10
dc.identifierpii: dju267
dc.identifier.citationIles, M. M., Bishop, D. T., Taylor, J. C., Hayward, N. K., Brossard, M., Cust, A. E., Dunning, A. M., Lee, J. E., Moses, E. K., Akslen, L. A., AMFS Investigators, , Andresen, P. A., Avril, M. -F., Azizi, E., Scarrà, G. B., Brown, K. M., Dębniak, T., Elder, D. E., Friedman, E. ,... GenoMEL Consortium, (2014). The effect on melanoma risk of genes previously associated with telomere length.. J Natl Cancer Inst, 106 (10), pp.dju267--. https://doi.org/10.1093/jnci/dju267.
dc.identifier.issn0027-8874
dc.identifier.urihttp://hdl.handle.net/11343/255081
dc.description.abstractTelomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10(-9), two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleThe effect on melanoma risk of genes previously associated with telomere length.
dc.typeJournal Article
dc.identifier.doi10.1093/jnci/dju267
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.source.titleJournal of the National Cancer Institute
melbourne.source.volume106
melbourne.source.issue10
melbourne.source.pagesdju267--
dc.rights.licenseCC BY
melbourne.elementsid1233856
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196080
melbourne.contributor.authorCUST, ANNE
dc.identifier.eissn1460-2105
melbourne.accessrightsOpen Access


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