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    Spatio-Temporal Regulation of Rac1 Mobility by Actin Islands.

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    Author
    Lakhani, VV; Hinde, E; Gratton, E; Elston, TC
    Date
    2015
    Source Title
    PLoS One
    Publisher
    Public Library of Science (PLoS)
    University of Melbourne Author/s
    Hinde, Elizabeth
    Affiliation
    School of Physics
    Metadata
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    Document Type
    Journal Article
    Citations
    Lakhani, V. V., Hinde, E., Gratton, E. & Elston, T. C. (2015). Spatio-Temporal Regulation of Rac1 Mobility by Actin Islands.. PLoS One, 10 (11), pp.e0143753-. https://doi.org/10.1371/journal.pone.0143753.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255087
    DOI
    10.1371/journal.pone.0143753
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659588
    Abstract
    Rho GTPases play important roles in many aspects of cell migration, including polarity establishment and organizing actin cytoskeleton. In particular, the Rho GTPase Rac1 has been associated with the generation of protrusions at leading edge of migrating cells. Previously we showed the mobility of Rac1 molecules is not uniform throughout a migrating cell (Hinde E et. al. PNAS 2013). Specifically, the closer a Rac1 molecule is to the leading edge, the slower the molecule diffuses. Because actin-bound Rac1 diffuses slower than unbound Rac1, we hypothesized that regions of high actin concentration, called "actin islands", act as diffusive traps and are responsible for the non-uniform diffusion observed in vivo. Here, in silico model simulations demonstrate that equally spaced actin islands can regulate the time scale for Rac1 diffusion in a manner consistent with data from live-cell imaging experiments. Additionally, we find this mechanism is robust; different patterns of Rac1 mobility can be achieved by changing the actin islands' positions or their affinity for Rac1.

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