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    Declining Transmission and Immunity to Malaria and Emerging Artemisinin Resistance in Thailand: A Longitudinal Study

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    Author
    Ataide, R; Powell, R; Moore, K; McLean, A; Phyo, AP; Nair, S; White, M; Anderson, TJ; Beeson, JG; Simpson, JA; ...
    Date
    2017-09-15
    Source Title
    Journal of Infectious Diseases
    Publisher
    OXFORD UNIV PRESS INC
    University of Melbourne Author/s
    Beeson, James; Simpson, Julie; Fowkes, Freya; Moore, Kerryn; Ataide, Ricardo
    Affiliation
    Medicine and Radiology
    Melbourne School of Population and Global Health
    Metadata
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    Document Type
    Journal Article
    Citations
    Ataide, R., Powell, R., Moore, K., McLean, A., Phyo, A. P., Nair, S., White, M., Anderson, T. J., Beeson, J. G., Simpson, J. A., Nosten, F. & Fowkes, F. J. I. (2017). Declining Transmission and Immunity to Malaria and Emerging Artemisinin Resistance in Thailand: A Longitudinal Study. JOURNAL OF INFECTIOUS DISEASES, 216 (6), pp.723-731. https://doi.org/10.1093/infdis/jix371.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255093
    DOI
    10.1093/infdis/jix371
    Abstract
    Background: Reductions in malaria transmission decrease naturally acquired immunity, which may influence the emergence of Plasmodium falciparum artemisinin-resistant phenotypes and genotypes over time. Methods: Antibodies specific for P. falciparum antigens were determined in uncomplicated hyperparasitemic malaria patients over a 10-year period of declining malaria transmission and emerging artemisinin resistance in northwestern Thailand. We investigated the association between antibody levels and both parasite clearance time (PCt½) and artemisinin resistance-associated kelch13 genotypes over time. Results: Immunity to P. falciparum declined prior to 2004, preceding the emergence of artemisinin resistance-associated genotypes and phenotypes (maximum mean change in antibody level per year: anti-MSP142 = -0.17; 95% confidence interval [CI] = -.31 to -.04; P = .01). In this period of declining immunity, and in the absence of kelch13 mutations, PCt½ increased. Between 2007 and 2011, levels of antibodies fluctuated, and higher antibody levels were associated with faster PCt½ (maximum yearly change in PCt½, in hours: EBA140rII = -0.39; 95% CI = -.61 to -.17; P < .001). Conclusions: Understanding the impact of changing transmission and immunity on the emergence of artemisinin resistance is important particularly as increased malaria control and elimination activities may enhance immunological conditions for the expansion of artemisinin-resistant P. falciparum.

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