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dc.contributor.authorAtaide, R
dc.contributor.authorPowell, R
dc.contributor.authorMoore, K
dc.contributor.authorMcLean, A
dc.contributor.authorPhyo, AP
dc.contributor.authorNair, S
dc.contributor.authorWhite, M
dc.contributor.authorAnderson, TJ
dc.contributor.authorBeeson, JG
dc.contributor.authorSimpson, JA
dc.contributor.authorNosten, F
dc.contributor.authorFowkes, FJI
dc.date.accessioned2020-12-17T03:55:55Z
dc.date.available2020-12-17T03:55:55Z
dc.date.issued2017-09-15
dc.identifierpii: 4061306
dc.identifier.citationAtaide, R., Powell, R., Moore, K., McLean, A., Phyo, A. P., Nair, S., White, M., Anderson, T. J., Beeson, J. G., Simpson, J. A., Nosten, F. & Fowkes, F. J. I. (2017). Declining Transmission and Immunity to Malaria and Emerging Artemisinin Resistance in Thailand: A Longitudinal Study. JOURNAL OF INFECTIOUS DISEASES, 216 (6), pp.723-731. https://doi.org/10.1093/infdis/jix371.
dc.identifier.issn0022-1899
dc.identifier.urihttp://hdl.handle.net/11343/255093
dc.description.abstractBackground: Reductions in malaria transmission decrease naturally acquired immunity, which may influence the emergence of Plasmodium falciparum artemisinin-resistant phenotypes and genotypes over time. Methods: Antibodies specific for P. falciparum antigens were determined in uncomplicated hyperparasitemic malaria patients over a 10-year period of declining malaria transmission and emerging artemisinin resistance in northwestern Thailand. We investigated the association between antibody levels and both parasite clearance time (PCt½) and artemisinin resistance-associated kelch13 genotypes over time. Results: Immunity to P. falciparum declined prior to 2004, preceding the emergence of artemisinin resistance-associated genotypes and phenotypes (maximum mean change in antibody level per year: anti-MSP142 = -0.17; 95% confidence interval [CI] = -.31 to -.04; P = .01). In this period of declining immunity, and in the absence of kelch13 mutations, PCt½ increased. Between 2007 and 2011, levels of antibodies fluctuated, and higher antibody levels were associated with faster PCt½ (maximum yearly change in PCt½, in hours: EBA140rII = -0.39; 95% CI = -.61 to -.17; P < .001). Conclusions: Understanding the impact of changing transmission and immunity on the emergence of artemisinin resistance is important particularly as increased malaria control and elimination activities may enhance immunological conditions for the expansion of artemisinin-resistant P. falciparum.
dc.languageEnglish
dc.publisherOXFORD UNIV PRESS INC
dc.titleDeclining Transmission and Immunity to Malaria and Emerging Artemisinin Resistance in Thailand: A Longitudinal Study
dc.typeJournal Article
dc.identifier.doi10.1093/infdis/jix371
melbourne.affiliation.departmentMedicine and Radiology
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.source.titleJournal of Infectious Diseases
melbourne.source.volume216
melbourne.source.issue6
melbourne.source.pages723-731
dc.rights.licenseCC BY
melbourne.elementsid1235305
melbourne.contributor.authorBeeson, James
melbourne.contributor.authorSimpson, Julie
melbourne.contributor.authorFowkes, Freya
melbourne.contributor.authorMoore, Kerryn
melbourne.contributor.authorAtaide, Ricardo
dc.identifier.eissn1537-6613
melbourne.accessrightsOpen Access


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