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    Focal therapy for prostate cancer: the technical challenges

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    Author
    Haworth, A; Williams, S
    Date
    2017-07-01
    Source Title
    Journal of Contemporary Brachytherapy
    Publisher
    TERMEDIA PUBLISHING HOUSE LTD
    University of Melbourne Author/s
    Williams, Scott; Haworth, Annette
    Affiliation
    Clinical Pathology
    Sir Peter MacCallum Department of Oncology
    Metadata
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    Document Type
    Journal Article
    Citations
    Haworth, A. & Williams, S. (2017). Focal therapy for prostate cancer: the technical challenges. JOURNAL OF CONTEMPORARY BRACHYTHERAPY, 9 (4), pp.383-389. https://doi.org/10.5114/jcb.2017.69809.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255109
    DOI
    10.5114/jcb.2017.69809
    Abstract
    Focal therapy for prostate cancer has been proposed as an alternative treatment to whole gland therapy, offering the opportunity for tumor dose escalation and/or reduced toxicity. Brachytherapy, either low-dose-rate or high-dose-rate, provides an ideal approach, offering both precision in dose delivery and opportunity for a highly conformal, non-uniform dose distribution. Whilst multiple consensus documents have published clinical guidelines for patient selection, there are insufficient data to provide clear guidelines on target volume delineation, treatment planning margins, treatment planning approaches, and many other technical issues that should be considered before implementing a focal brachytherapy program. Without consensus guidelines, there is the potential for a diversity of practices to develop, leading to challenges in interpreting outcome data from multiple centers. This article provides an overview of the technical considerations for the implementation of a clinical service, and discusses related topics that should be considered in the design of clinical trials to ensure precise and accurate methods are applied for focal brachytherapy treatments.

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