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    Evaluation of Nonmotor Symptoms in Diagnosis of Parkinsonism and Tremor

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    Author
    Evans, AH; Chai, C-H
    Date
    2016-01-01
    Source Title
    Parkinson's Disease
    Publisher
    HINDAWI LTD
    University of Melbourne Author/s
    Evans, Andrew
    Affiliation
    Medicine and Radiology
    Metadata
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    Document Type
    Journal Article
    Citations
    Evans, A. H. & Chai, C. -H. (2016). Evaluation of Nonmotor Symptoms in Diagnosis of Parkinsonism and Tremor. PARKINSONS DISEASE, 2016, https://doi.org/10.1155/2016/9182946.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255115
    DOI
    10.1155/2016/9182946
    Abstract
    Background. Nonmotor symptoms particularly olfactory dysfunction, RBD, depression, hallucinations, and constipation are currently not included in the typical clinical criteria for diagnosing Lewy body Parkinsonian disorders (LBPD). The aim of this study is to determine the diagnostic value of nonmotor symptoms in patients presenting with Parkinsonism and tremor. Methods. All new patients seen between January 2007 and May 2013 in the Movement Disorders Specialist Clinics of the Royal Melbourne Hospital (RMH), who were referred with a possible neurodegenerative syndrome or concerns of Parkinsonism and/or tremor, were included. Patients underwent routine evaluation with the four-minute "Sniffin Sticks" test, RBD, depression, and constipation. Results. 291 patients were included in the analysis. Conclusion. We found that lower olfaction scores based on "Sniffin Sticks" testing combined with reports of depression and constipation are independent predictors for the diagnosis of the spectrum of Lewy body Parkinsonian disorders (LBPD). Parkinson's disease (PD) cannot be reliably clinically differentiated from other causes of Parkinsonism that share symptomatology and structural abnormalities.

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