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    Roadmap for investigating epigenome deregulation and environmental origins of cancer

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    Author
    Herceg, Z; Ghantous, A; Wild, CP; Sklias, A; Casati, L; Duthie, SJ; Fry, R; Issa, J-P; Kellermayer, R; Koturbash, I; ...
    Date
    2018-03-01
    Source Title
    International Journal of Cancer
    Publisher
    WILEY
    University of Melbourne Author/s
    Saffery, Richard
    Affiliation
    Paediatrics (RCH)
    Metadata
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    Document Type
    Journal Article
    Citations
    Herceg, Z., Ghantous, A., Wild, C. P., Sklias, A., Casati, L., Duthie, S. J., Fry, R., Issa, J. -P., Kellermayer, R., Koturbash, I., Kondo, Y., Lepeule, J., Lima, S. C. S., Marsit, C. J., Rakyan, V., Saffery, R., Taylor, J. A., Teschendorff, A. E., Ushijima, T. ,... Hernandez-Vargas, H. (2018). Roadmap for investigating epigenome deregulation and environmental origins of cancer. INTERNATIONAL JOURNAL OF CANCER, 142 (5), pp.874-882. https://doi.org/10.1002/ijc.31014.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255123
    DOI
    10.1002/ijc.31014
    Abstract
    The interaction between the (epi)genetic makeup of an individual and his/her environmental exposure record (exposome) is accepted as a determinant factor for a significant proportion of human malignancies. Recent evidence has highlighted the key role of epigenetic mechanisms in mediating gene-environment interactions and translating exposures into tumorigenesis. There is also growing evidence that epigenetic changes may be risk factor-specific ("fingerprints") that should prove instrumental in the discovery of new biomarkers in cancer. Here, we review the state of the science of epigenetics associated with environmental stimuli and cancer risk, highlighting key developments in the field. Critical knowledge gaps and research needs are discussed and advances in epigenomics that may help in understanding the functional relevance of epigenetic alterations. Key elements required for causality inferences linking epigenetic changes to exposure and cancer are discussed and how these alterations can be incorporated in carcinogen evaluation and in understanding mechanisms underlying epigenome deregulation by the environment.

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