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dc.contributor.authorDeliyanti, D
dc.contributor.authorTalia, DM
dc.contributor.authorZhu, T
dc.contributor.authorMaxwell, MJ
dc.contributor.authorAgrotis, A
dc.contributor.authorJerome, JR
dc.contributor.authorHargreaves, EM
dc.contributor.authorGerondakis, S
dc.contributor.authorHibbs, ML
dc.contributor.authorMackay, F
dc.contributor.authorWilkinson-Berka, JL
dc.date.accessioned2020-12-17T04:02:04Z
dc.date.available2020-12-17T04:02:04Z
dc.date.issued2017-09-29
dc.identifierpii: 10.1038/s41467-017-00751-w
dc.identifier.citationDeliyanti, D., Talia, D. M., Zhu, T., Maxwell, M. J., Agrotis, A., Jerome, J. R., Hargreaves, E. M., Gerondakis, S., Hibbs, M. L., Mackay, F. & Wilkinson-Berka, J. L. (2017). Foxp3(+) Tregs are recruited to the retina to repair pathological angiogenesis. NATURE COMMUNICATIONS, 8 (1), https://doi.org/10.1038/s41467-017-00751-w.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/255133
dc.description.abstractNeovascular retinopathies are major causes of vision loss; yet treatments to prevent the condition are inadequate. The role of regulatory T cells in neovascular retinopathy is unknown. Here we show that in retinopathy regulatory T cells are transiently increased in lymphoid organs and the retina, but decline when neovascularization is established. The decline is prevented following regulatory T cells expansion with an IL-2/anti-IL-2 mAb complex or the adoptive transfer of regulatory T cells. Further, both approaches reduce vasculopathy (vaso-obliteration, neovascularization, vascular leakage) and alter the activation of Tmem119+ retinal microglia. Our in vitro studies complement these findings, showing that retinal microglia co-cultured with regulatory T cells exhibit a reduction in co-stimulatory molecules and pro-inflammatory mediators that is attenuated by CTLA-4 blockade. Collectively, we demonstrate that regulatory T cells are recruited to the retina and, when expanded in number, repair the vasculature. Manipulation of regulatory T cell numbers is a previously unrecognized, and promising avenue for therapies to prevent blinding neovascular retinopathies.The local immune responses in the eye are attenuated to preserve sight. Surprisingly, Deliyanti et al. show that regulatory T cells (Tregs) take an active role in protecting the eye from neovascularization in oxygen-induced retinopathy, and that interventions that augment the retinal Treg numbers reduce neovascular retinopathy in mice.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleFoxp3(+) Tregs are recruited to the retina to repair pathological angiogenesis
dc.typeJournal Article
dc.identifier.doi10.1038/s41467-017-00751-w
melbourne.affiliation.departmentSchool of Biomedical Sciences
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentAnatomy and Neuroscience
melbourne.source.titleNature Communications
melbourne.source.volume8
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1240604
melbourne.contributor.authorMackay, Fabienne
melbourne.contributor.authorWilkinson-Berka, Jennifer
melbourne.contributor.authorDeliyanti, Devy
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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