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    Analysis of Behavior and Trafficking of Dendritic Cells within the Brain during Toxoplasmic Encephalitis

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    Author
    John, B; Ricart, B; Wojno, EDT; Harris, TH; Randall, LM; Christian, DA; Gregg, B; De Almeida, DM; Weninger, W; Hammer, DA; ...
    Date
    2011-09-01
    Source Title
    PLoS Pathogens
    Publisher
    PUBLIC LIBRARY SCIENCE
    University of Melbourne Author/s
    Randall, Louise
    Affiliation
    Medicine and Radiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    John, B., Ricart, B., Wojno, E. D. T., Harris, T. H., Randall, L. M., Christian, D. A., Gregg, B., De Almeida, D. M., Weninger, W., Hammer, D. A. & Hunter, C. A. (2011). Analysis of Behavior and Trafficking of Dendritic Cells within the Brain during Toxoplasmic Encephalitis. PLOS PATHOGENS, 7 (9), https://doi.org/10.1371/journal.ppat.1002246.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255184
    DOI
    10.1371/journal.ppat.1002246
    Abstract
    Under normal conditions the immune system has limited access to the brain; however, during toxoplasmic encephalitis (TE), large numbers of T cells and APCs accumulate within this site. A combination of real time imaging, transgenic reporter mice, and recombinant parasites allowed a comprehensive analysis of CD11c+ cells during TE. These studies reveal that the CNS CD11c+ cells consist of a mixture of microglia and dendritic cells (DCs) with distinct behavior associated with their ability to interact with parasites or effector T cells. The CNS DCs upregulated several chemokine receptors during TE, but none of these individual receptors tested was required for migration of DCs into the brain. However, this process was pertussis toxin sensitive and dependent on the integrin LFA-1, suggesting that the synergistic effect of signaling through multiple chemokine receptors, possibly leading to changes in the affinity of LFA-1, is involved in the recruitment/retention of DCs to the CNS and thus provides new insights into how the immune system accesses this unique site.

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