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dc.contributor.authorJohn, B
dc.contributor.authorRicart, B
dc.contributor.authorWojno, EDT
dc.contributor.authorHarris, TH
dc.contributor.authorRandall, LM
dc.contributor.authorChristian, DA
dc.contributor.authorGregg, B
dc.contributor.authorDe Almeida, DM
dc.contributor.authorWeninger, W
dc.contributor.authorHammer, DA
dc.contributor.authorHunter, CA
dc.date.accessioned2020-12-17T04:09:08Z
dc.date.available2020-12-17T04:09:08Z
dc.date.issued2011-09-01
dc.identifierpii: PPATHOGENS-D-11-00831
dc.identifier.citationJohn, B., Ricart, B., Wojno, E. D. T., Harris, T. H., Randall, L. M., Christian, D. A., Gregg, B., De Almeida, D. M., Weninger, W., Hammer, D. A. & Hunter, C. A. (2011). Analysis of Behavior and Trafficking of Dendritic Cells within the Brain during Toxoplasmic Encephalitis. PLOS PATHOGENS, 7 (9), https://doi.org/10.1371/journal.ppat.1002246.
dc.identifier.issn1553-7366
dc.identifier.urihttp://hdl.handle.net/11343/255184
dc.description.abstractUnder normal conditions the immune system has limited access to the brain; however, during toxoplasmic encephalitis (TE), large numbers of T cells and APCs accumulate within this site. A combination of real time imaging, transgenic reporter mice, and recombinant parasites allowed a comprehensive analysis of CD11c+ cells during TE. These studies reveal that the CNS CD11c+ cells consist of a mixture of microglia and dendritic cells (DCs) with distinct behavior associated with their ability to interact with parasites or effector T cells. The CNS DCs upregulated several chemokine receptors during TE, but none of these individual receptors tested was required for migration of DCs into the brain. However, this process was pertussis toxin sensitive and dependent on the integrin LFA-1, suggesting that the synergistic effect of signaling through multiple chemokine receptors, possibly leading to changes in the affinity of LFA-1, is involved in the recruitment/retention of DCs to the CNS and thus provides new insights into how the immune system accesses this unique site.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleAnalysis of Behavior and Trafficking of Dendritic Cells within the Brain during Toxoplasmic Encephalitis
dc.typeJournal Article
dc.identifier.doi10.1371/journal.ppat.1002246
melbourne.affiliation.departmentInfectious Diseases
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titlePLoS Pathogens
melbourne.source.volume7
melbourne.source.issue9
dc.rights.licenseCC BY
melbourne.elementsid1243037
melbourne.contributor.authorRandall, Louise
dc.identifier.eissn1553-7374
melbourne.accessrightsOpen Access


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