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    Plasma amyloid β 42/40 ratios as biomarkers for amyloid β cerebral deposition in cognitively normal individuals.

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    Author
    Fandos, N; Pérez-Grijalba, V; Pesini, P; Olmos, S; Bossa, M; Villemagne, VL; Doecke, J; Fowler, C; Masters, CL; Sarasa, M; ...
    Date
    2017
    Source Title
    Alzheimer's & dementia (Amsterdam, Netherlands)
    Publisher
    Wiley
    University of Melbourne Author/s
    Villemagne, Victor; Fowler, Christopher; Masters, Colin
    Affiliation
    Florey Department of Neuroscience and Mental Health
    Medicine and Radiology
    Metadata
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    Document Type
    Journal Article
    Citations
    Fandos, N., Pérez-Grijalba, V., Pesini, P., Olmos, S., Bossa, M., Villemagne, V. L., Doecke, J., Fowler, C., Masters, C. L., Sarasa, M. & AIBL Research Group (2017). Plasma amyloid β 42/40 ratios as biomarkers for amyloid β cerebral deposition in cognitively normal individuals.. Alzheimers Dement (Amst), 8 (1), pp.179-187. https://doi.org/10.1016/j.dadm.2017.07.004.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255185
    DOI
    10.1016/j.dadm.2017.07.004
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602863
    Abstract
    INTRODUCTION: Plasma amyloid β (Aβ) peptides have been previously studied as candidate biomarkers to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. METHODS: Free and total Aβ42/40 plasma ratios (FP42/40 and TP42/40, respectively) were determined using ABtest assays in cognitively normal subjects from the Australian Imaging, Biomarker and Lifestyle Flagship Study. This population was followed-up for 72 months and their cortical Aβ burden was assessed with positron emission tomography. RESULTS: Cross-sectional and longitudinal analyses showed an inverse association of Aβ42/40 plasma ratios and cortical Aβ burden. Optimized as a screening tool, TP42/40 reached 81% positive predictive value of high cortical Aβ burden, which represents 110% increase over the population prevalence of cortical Aβ positivity. DISCUSSION: These findings support the use of plasma Aβ42/40 ratios as surrogate biomarkers of cortical Aβ deposition and enrichment tools, reducing the number of subjects submitted to invasive tests and, consequently, recruitment costs in clinical trials targeting cognitively normal individuals.

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