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    Cardiomyocyte Functional Etiology in Heart Failure With Preserved Ejection Fraction Is Distinctive-A New Preclinical Model

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    Author
    Curl, CL; Danes, VR; Bell, JR; Raaijmakers, AJA; Ip, WTK; Chandramouli, C; Harding, TW; Porrello, ER; Erickson, JR; Charchar, FJ; ...
    Date
    2018-06-05
    Source Title
    Journal of the American Heart Association
    Publisher
    WILEY
    University of Melbourne Author/s
    Edgley, Amanda; Curl, Claire; Porrello, Enzo; Charchar, Fadi; Kompa, Andrew; Mellor, Kimberley; Kalman, Jonathan; Harrap, Stephen; Delbridge, Leanne; Bell, James
    Affiliation
    Medicine and Radiology
    Physiology
    Metadata
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    Document Type
    Journal Article
    Citations
    Curl, C. L., Danes, V. R., Bell, J. R., Raaijmakers, A. J. A., Ip, W. T. K., Chandramouli, C., Harding, T. W., Porrello, E. R., Erickson, J. R., Charchar, F. J., Kompa, A. R., Edgley, A. J., Crossman, D. J., Soeller, C., Mellor, K. M., Kalman, J. M., Harrap, S. & Delbridge, L. M. D. (2018). Cardiomyocyte Functional Etiology in Heart Failure With Preserved Ejection Fraction Is Distinctive-A New Preclinical Model. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 7 (11), https://doi.org/10.1161/JAHA.117.007451.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255204
    DOI
    10.1161/JAHA.117.007451
    Abstract
    BACKGROUND: Among the growing numbers of patients with heart failure, up to one half have heart failure with preserved ejection fraction (HFpEF). The lack of effective treatments for HFpEF is a substantial and escalating unmet clinical need-and the lack of HFpEF-specific animal models represents a major preclinical barrier in advancing understanding of HFpEF. As established treatments for heart failure with reduced ejection fraction (HFrEF) have proven ineffective for HFpEF, the contention that the intrinsic cardiomyocyte phenotype is distinct in these 2 conditions requires consideration. Our goal was to validate and characterize a new rodent model of HFpEF, undertaking longitudinal investigations to delineate the associated cardiac and cardiomyocyte pathophysiology. METHODS AND RESULTS: The selectively inbred Hypertrophic Heart Rat (HHR) strain exhibits adult cardiac enlargement (without hypertension) and premature death (40% mortality at 50 weeks) compared to its control strain, the normal heart rat. Hypertrophy was characterized in vivo by maintained systolic parameters (ejection fraction at 85%-90% control) with marked diastolic dysfunction (increased E/E'). Surprisingly, HHR cardiomyocytes were hypercontractile, exhibiting high Ca2+ operational levels and markedly increased L-type Ca2+ channel current. In HHR, prominent regions of reparative fibrosis in the left ventricle free wall adjacent to the interventricular septum were observed. CONCLUSIONS: Thus, the cardiomyocyte remodeling process in the etiology of this HFpEF model contrasts dramatically with the suppressed Ca2+ cycling state that typifies heart failure with reduced ejection fraction. These findings may explain clinical observations, that treatments considered appropriate for heart failure with reduced ejection fraction are of little benefit for HFpEF-and suggest a basis for new therapeutic strategies.

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