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    Impact of Different Childhood Adversities on 1-Year Outcomes of Psychotic Disorder in the Genetics and Psychosis Study.

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    Author
    Trotta, A; Murray, RM; David, AS; Kolliakou, A; O'Connor, J; Di Forti, M; Dazzan, P; Mondelli, V; Morgan, C; Fisher, HL
    Date
    2016-03
    Source Title
    Schizophrenia Bulletin
    Publisher
    Oxford University Press (OUP)
    University of Melbourne Author/s
    Murray, Robin
    Affiliation
    Medical Education
    Metadata
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    Document Type
    Journal Article
    Citations
    Trotta, A., Murray, R. M., David, A. S., Kolliakou, A., O'Connor, J., Di Forti, M., Dazzan, P., Mondelli, V., Morgan, C. & Fisher, H. L. (2016). Impact of Different Childhood Adversities on 1-Year Outcomes of Psychotic Disorder in the Genetics and Psychosis Study.. Schizophr Bull, 42 (2), pp.464-475. https://doi.org/10.1093/schbul/sbv131.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255216
    DOI
    10.1093/schbul/sbv131
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753600
    Abstract
    While the role of childhood adversity in increasing the risk of psychosis has been extensively investigated, it is not clear what the impact of early adverse experiences is on the outcomes of psychotic disorders. Therefore, we investigated associations between childhood adversity and 1-year outcomes in 285 first-presentation psychosis patients. Exposure to childhood adversity prior to 17 years of age was assessed using the Childhood Experience of Care and Abuse Questionnaire. Data on illness course, symptom remission, length of psychiatric hospitalization, compliance with medication, employment, and relationship status were extracted from clinical records for the year following first contact with mental health services for psychosis. Seventy-one percent of patients reported exposure to at least 1 type of childhood adversity (physical abuse, sexual abuse, parental separation, parental death, disrupted family arrangements, or being taken into care). No robust associations were found between childhood adversity and illness course or remission. However, childhood physical abuse was associated with almost 3-fold increased odds of not being in a relationship at 1-year follow-up compared to patients who did not report such adverse experiences. There was also evidence of a significant association between parental separation in childhood and longer admissions to psychiatric wards during 1-year follow-up and 2-fold increased odds of noncompliance with medication compared to those not separated from their parents. Therefore, our findings suggest that there may be some specificity in the impact of childhood adversity on service use and social functioning among psychosis patients over the first year following presentation to mental health services.

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