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dc.contributor.authorDi Nicola, M
dc.contributor.authorCattaneo, A
dc.contributor.authorHepgul, N
dc.contributor.authorDi Forti, M
dc.contributor.authorAitchison, KJ
dc.contributor.authorJaniri, L
dc.contributor.authorMurray, RM
dc.contributor.authorDazzan, P
dc.contributor.authorPariante, CM
dc.contributor.authorMondelli, V
dc.date.accessioned2020-12-17T04:13:52Z
dc.date.available2020-12-17T04:13:52Z
dc.date.issued2013-07
dc.identifierpii: S0889-1591(12)00152-3
dc.identifier.citationDi Nicola, M., Cattaneo, A., Hepgul, N., Di Forti, M., Aitchison, K. J., Janiri, L., Murray, R. M., Dazzan, P., Pariante, C. M. & Mondelli, V. (2013). Serum and gene expression profile of cytokines in first-episode psychosis.. Brain Behav Immun, 31, pp.90-95. https://doi.org/10.1016/j.bbi.2012.06.010.
dc.identifier.issn0889-1591
dc.identifier.urihttp://hdl.handle.net/11343/255218
dc.description.abstractAn inflammatory syndrome has been previously reported in chronic schizophrenia. The aims of this study were to investigate: (1) serum levels and leukocyte gene expression of cytokines in patients with first-episode psychosis and controls; and (2) possible causes of abnormal cytokine levels in first-episode psychosis, testing their association with psychosocial stressors, current nicotine and cannabis use, and duration of antipsychotic treatment. We recruited 24 first-episode psychosis patients and 24 healthy controls matched for age, gender, ethnicity and body mass index. Serum interleukin(IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, Tumour Necrosis Factor- α (TNF-α), Interferon- γ (IFN-γ), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and monocyte chemotactic protein-1 (MCP-1) were analysed in all subjects. Leukocyte gene expression analyses were conducted only for those cytokines that were different between-groups in the serum analyses. Patients had significantly higher serum levels of IL-1α (effect size d=0.6, p=0.03), IL-1β (d=0.4, p=0.01), IL-8 (d=0.6, p=0.01) and TNF-α (d=0.7, p=0.05) and a trend for higher IL-6 serum levels (d=0.3, p=0.09) when compared with controls. Leukocyte m-RNA levels of IL-1α (d=0.6, p=0.04), IL-6 (d=0.7, p=0.01) and TNF-α (d=1.6, p<0.001), but not IL-1β and IL-8, were also significantly higher in patients. A history of childhood trauma was associated with higher TNF-α serum levels (p=0.01), while more recent stressful life-events were associated with higher TNF-α mRNA levels in leukocytes (p=0.002). In conclusion, first-episode psychosis is characterised by a pro-inflammatory state supported, at least in part, by activation of leukocytes. Past and recent stressors contribute to this pro-inflammatory state.
dc.languageeng
dc.publisherElsevier BV
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleSerum and gene expression profile of cytokines in first-episode psychosis.
dc.typeJournal Article
dc.identifier.doi10.1016/j.bbi.2012.06.010
melbourne.affiliation.departmentMedical Education
melbourne.source.titleBrain, Behavior, and Immunity
melbourne.source.volume31
melbourne.source.pages90-95
dc.rights.licenseCC BY
melbourne.elementsid1334566
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675681
melbourne.contributor.authorMurray, Robin
dc.identifier.eissn1090-2139
melbourne.accessrightsOpen Access


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