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    Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017

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    Author
    Clayton, A; Buschmann, D; Byrd, JB; Carter, DRF; Cheng, L; Compton, C; Daaboul, G; Devitt, A; Manuel Falcon-Perez, J; Gardiner, C; ...
    Date
    2018-05-17
    Source Title
    Journal of Extracellular Vesicles
    Publisher
    TAYLOR & FRANCIS LTD
    University of Melbourne Author/s
    Hill, Andrew; Cheng, Lesley
    Affiliation
    University General
    Biochemistry and Molecular Biology
    Metadata
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    Document Type
    Journal Article
    Citations
    Clayton, A., Buschmann, D., Byrd, J. B., Carter, D. R. F., Cheng, L., Compton, C., Daaboul, G., Devitt, A., Manuel Falcon-Perez, J., Gardiner, C., Gustafson, D., Harrison, P., Helmbrecht, C., Hendrix, A., Hill, A., Hoffman, A., Jones, J. C., Kalluri, R., Kang, J. Y. ,... Nieuwland, R. (2018). Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017. JOURNAL OF EXTRACELLULAR VESICLES, 7 (1), https://doi.org/10.1080/20013078.2018.1473707.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255225
    DOI
    10.1080/20013078.2018.1473707
    Abstract
    This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.

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