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dc.contributor.authorLee, Y-EC
dc.contributor.authorWilliams, DR
dc.contributor.authorAnderson, JFI
dc.date.accessioned2020-12-17T04:16:58Z
dc.date.available2020-12-17T04:16:58Z
dc.date.issued2018-05-01
dc.identifierpii: jmd-17067
dc.identifier.citationLee, Y. -E. C., Williams, D. R. & Anderson, J. F. I. (2018). Prospective Characterization of Cognitive Function in Typical and 'Brainstem Predominant' Progressive Supranuclear Palsy Phenotypes. JOURNAL OF MOVEMENT DISORDERS, 11 (2), pp.72-77. https://doi.org/10.14802/jmd.17067.
dc.identifier.issn2005-940X
dc.identifier.urihttp://hdl.handle.net/11343/255240
dc.description.abstractOBJECTIVE: Clinicopathological studies over the last decade have broadened the clinical spectrum of progressive supranuclear palsy (PSP) to include several distinct clinical syndromes. We examined the cognitive profiles of patients with PSP-Richardson's syndrome (PSP-RS) and two atypical 'brainstem predominant' PSP phenotypes (PSP-parkinsonism, PSP-P; and PSP-pure akinesia with gait freezing, PSP-PAGF) using a comprehensive neuropsychological battery. METHODS: Fourteen patients diagnosed as PSP-RS, three patients with PSP-P and four patients with PSP-PAGF were assessed using a comprehensive battery of neuropsychological tests. RESULTS: The typical PSP-RS subgroup demonstrated greater impairments in processing speed [t(19) = -4.10, p = 0.001 (d =1.66)] and executive function [t(19) = -2.63, p = 0.02 (d = 1.20)] compared to the 'brainstem predominant' PSP phenotype. CONCLUSION: This is the first prospective study to demonstrate that PSP-RS and 'brainstem predominant' PSP phenotypes can be differentiated on cognitive grounds. These differences correspond with variations in pathological profiles reported in the literature.
dc.languageEnglish
dc.publisherKOREAN MOVEMENT DISORDERS SOC
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titleProspective Characterization of Cognitive Function in Typical and 'Brainstem Predominant' Progressive Supranuclear Palsy Phenotypes
dc.typeJournal Article
dc.identifier.doi10.14802/jmd.17067
melbourne.affiliation.departmentMelbourne School of Psychological Sciences
melbourne.affiliation.departmentMelbourne Conservatorium of Music
melbourne.source.titleJournal of Movement Disorders
melbourne.source.volume11
melbourne.source.issue2
melbourne.source.pages72-77
dc.rights.licenseCC BY-NC
melbourne.elementsid1332781
melbourne.contributor.authorAnderson, Jacqueline
melbourne.contributor.authorLee, Young-Eun
dc.identifier.eissn2093-4939
melbourne.accessrightsOpen Access


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