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dc.contributor.authorJohanson, TM
dc.contributor.authorCoughlan, HD
dc.contributor.authorLun, ATL
dc.contributor.authorBediaga, NG
dc.contributor.authorNaselli, G
dc.contributor.authorGarnham, AL
dc.contributor.authorHarrison, LC
dc.contributor.authorSmyth, GK
dc.contributor.authorAllan, RS
dc.date.accessioned2020-12-17T04:18:25Z
dc.date.available2020-12-17T04:18:25Z
dc.date.issued2018-06-01
dc.identifierpii: PGENETICS-D-17-02369
dc.identifier.citationJohanson, T. M., Coughlan, H. D., Lun, A. T. L., Bediaga, N. G., Naselli, G., Garnham, A. L., Harrison, L. C., Smyth, G. K. & Allan, R. S. (2018). Genome-wide analysis reveals no evidence of trans chromosomal regulation of mammalian immune development. PLOS GENETICS, 14 (6), https://doi.org/10.1371/journal.pgen.1007431.
dc.identifier.issn1553-7404
dc.identifier.urihttp://hdl.handle.net/11343/255251
dc.description.abstractIt has been proposed that interactions between mammalian chromosomes, or transchromosomal interactions (also known as kissing chromosomes), regulate gene expression and cell fate determination. Here we aimed to identify novel transchromosomal interactions in immune cells by high-resolution genome-wide chromosome conformation capture. Although we readily identified stable interactions in cis, and also between centromeres and telomeres on different chromosomes, surprisingly we identified no gene regulatory transchromosomal interactions in either mouse or human cells, including previously described interactions. We suggest that advances in the chromosome conformation capture technique and the unbiased nature of this approach allow more reliable capture of interactions between chromosomes than previous methods. Overall our findings suggest that stable transchromosomal interactions that regulate gene expression are not present in mammalian immune cells and that lineage identity is governed by cis, not trans chromosomal interactions.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleGenome-wide analysis reveals no evidence of trans chromosomal regulation of mammalian immune development
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pgen.1007431
melbourne.affiliation.departmentSchool of Mathematics and Statistics
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titlePLoS Genetics
melbourne.source.volume14
melbourne.source.issue6
dc.rights.licenseCC BY
melbourne.elementsid1334350
melbourne.contributor.authorSmyth, Gordon
melbourne.contributor.authorGarnham, Alexandra
melbourne.contributor.authorJohanson, Timothy
melbourne.contributor.authorHarrison, Leonard
melbourne.contributor.authorAllan, Rhys
melbourne.contributor.authorCoughlan, Hannah
melbourne.contributor.authorLun, Aaron Tin Long
dc.identifier.eissn1553-7404
melbourne.accessrightsOpen Access


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