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dc.contributor.authorTao, C
dc.contributor.authorSimpson, S
dc.contributor.authorTaylor, BV
dc.contributor.authorBlizzard, L
dc.contributor.authorLucas, RM
dc.contributor.authorPonsonby, A-L
dc.contributor.authorBroadley, S
dc.contributor.authorvan der Mei, I
dc.date.accessioned2020-12-17T04:19:12Z
dc.date.available2020-12-17T04:19:12Z
dc.date.issued2018-06-08
dc.identifier.citationTao, C., Simpson, S., Taylor, B. V., Blizzard, L., Lucas, R. M., Ponsonby, A. -L., Broadley, S. & van der Mei, I. (2018). Onset Symptoms, Tobacco Smoking, and Progressive-Onset Phenotype Are Associated With a Delayed Onset of Multiple Sclerosis, and Marijuana Use With an Earlier Onset. FRONTIERS IN NEUROLOGY, 9 (JUN), https://doi.org/10.3389/fneur.2018.00418.
dc.identifier.issn1664-2295
dc.identifier.urihttp://hdl.handle.net/11343/255257
dc.description.abstractBackground: Age at symptom onset (ASO) is a prognostic factor that could affect the accrual of disability in multiple sclerosis (MS) patients. Some factors are known to influence the risk of multiple sclerosis (MS), but their influence on the ASO is less well-investigated. Objective: Examine the associations between known or emerging MS risk factors and ASO. Methods: This was a multicenter study, incident cases (n = 279) with first clinical diagnosis of demyelinating event aged 18-59 years recruited at four Australian centres (latitudes 27°-43°S), from 1 November 2003 to 31 December 2006. Environmental/behavioral variables and initial symptoms were recorded at baseline interview. Linear regression was used to assess the association between risk factors and ASO. Results: Five factors were significantly associated with ASO: a history of tobacco smoking was associated with 3.05-years later ASO (p = 0.002); a history of marijuana use was associated with 6.03-years earlier ASO (p < 0.001); progressive-onset cases had 5.61-years later ASO (p = 0.001); an initial presentation of bowel & bladder and cerebral dysfunctional were associated with 3.39 (p = 0.017) and 4.37-years (p = 0.006) later ASO, respectively. Other factors, including sex, offspring number, latitude of study site, history of infectious mononucleosis, HLA-DR15 & HLA-A2 genotype, 25(OH)D levels, and ultraviolet radiation exposure were not associated with ASO. Including all five significant variables into one model explained 12% of the total variance in ASO. Conclusion: We found a novel association between a history of tobacco smoking and later onset, whereas marijuana use was associated with earlier onset. Behavioral factors seem important drivers of MS onset timing although much of the variance remains unexplained.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.titleOnset Symptoms, Tobacco Smoking, and Progressive-Onset Phenotype Are Associated With a Delayed Onset of Multiple Sclerosis, and Marijuana Use With an Earlier Onset
dc.typeJournal Article
dc.identifier.doi10.3389/fneur.2018.00418
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.source.titleFrontiers in Neurology
melbourne.source.volume9
melbourne.source.issueJUN
dc.rights.licenseCC BY
melbourne.elementsid1336949
melbourne.contributor.authorSimpson-Yap, Steve
melbourne.contributor.authorPonsonby, Anne-Louise
dc.identifier.eissn1664-2295
melbourne.accessrightsOpen Access


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