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    Debates in Allergy Medicine: Oral immunotherapy shortens the duration of milk and egg allergy - the con argument

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    Author
    Loh, W; Tang, MLK
    Date
    2018-06-15
    Source Title
    The World Allergy Organization Journal
    Publisher
    BMC
    University of Melbourne Author/s
    Tang, Mimi
    Affiliation
    Paediatrics (RCH)
    Metadata
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    Document Type
    Journal Article
    Citations
    Loh, W. & Tang, M. L. K. (2018). Debates in Allergy Medicine: Oral immunotherapy shortens the duration of milk and egg allergy - the con argument. WORLD ALLERGY ORGANIZATION JOURNAL, 11 (1), https://doi.org/10.1186/s40413-018-0189-0.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255262
    DOI
    10.1186/s40413-018-0189-0
    Abstract
    Oral immunotherapy (OIT) has been shown to be effective for inducing desensitization in children with cow's milk and egg allergy. In contrast, there is limited evidence that OIT can induce tolerance or sustained unresponsiveness in food allergic patients. Sustained unresponsiveness, determined by a food challenge following a period of secondary avoidance, has been suggested to reflect a more enduring state of tolerance and is pertinent when considering the ability of OIT to shorten the duration of food allergy. While it has been shown that children who tolerate baked forms of egg and milk are more likely to develop tolerance compared to those who are allergic to baked forms of these foods, there is no convincing evidence that OIT using modified allergen in baked foods can hasten resolution of cow's milk and egg allergy. Instead, it is likely that baked milk and baked egg tolerant children represent a sub-phenotype of milk and egg allergy that is more likely to resolve spontaneously over time.

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