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dc.contributor.authorDuncan, RE
dc.contributor.authorDelatycki, MB
dc.contributor.authorCollins, SJ
dc.contributor.authorBoyd, A
dc.contributor.authorMasters, CL
dc.contributor.authorSavulescu, J
dc.date.available2014-05-21T19:00:19Z
dc.date.issued2005-11-01
dc.identifierpii: 31/11/625
dc.identifier.citationDuncan, R. E., Delatycki, M. B., Collins, S. J., Boyd, A., Masters, C. L. & Savulescu, J. (2005). Ethical considerations in presymptomatic testing for variant CJD. JOURNAL OF MEDICAL ETHICS, 31 (11), pp.625-630. https://doi.org/10.1136/jme.2005.011965.
dc.identifier.issn0306-6800
dc.identifier.urihttp://hdl.handle.net/11343/25526
dc.descriptionC1 - Journal Articles Refereed
dc.description.abstractVariant Creutzfeldt-Jakob disease (vCJD) is a fatal, transmissible, neurodegenerative disorder for which there is currently no effective treatment. vCJD arose from the zoonotic spread of bovine spongiform encephalopathy. There is now compelling evidence for human to human transmission through blood transfusions from presymptomatic carriers and experts are warning that the real epidemic may be yet to come. Imperatives exist for the development of reliable, non-invasive presymptomatic diagnostic tests. Research into such tests is well advanced. In this article the ethical implications of the availability of these tests are elaborated and comparisons drawn with predictive genetic testing for Huntington's disease and screening for HIV. Paramount to considerations is the issue of whom to test, weighing up respect for personal autonomy against obligations to benefit and protect society. A paradigm is proposed similar to that used for HIV screening but with unique features: compulsory testing of all blood/organ donors and individuals undergoing surgery or invasive procedures who have a significant risk of disease transmission.
dc.formatapplication/pdf
dc.languageEnglish
dc.publisherBMJ PUBLISHING GROUP
dc.subjectCentral Nervous System ; Infectious Diseases
dc.titleEthical considerations in presymptomatic testing for variant CJD
dc.typeJournal Article
dc.identifier.doi10.1136/jme.2005.011965
melbourne.peerreviewPeer Reviewed
melbourne.affiliationThe University of Melbourne
melbourne.affiliation.departmentPaediatrics Royal Children'S Hospital
melbourne.source.titleJournal of Medical Ethics
melbourne.source.volume31
melbourne.source.issue11
melbourne.source.pages625-630
melbourne.publicationid43743
melbourne.elementsid273634
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1734042
melbourne.contributor.authorDUNCAN, RONY EMILY
melbourne.contributor.authorDelatycki, Martin
melbourne.contributor.authorCollins, Steven
melbourne.contributor.authorBOYD, ALISON
melbourne.contributor.authorMasters, Colin
melbourne.contributor.authorSavulescu, Julian
dc.identifier.eissn1473-4257
melbourne.accessrightsAccess this item via the Open Access location


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