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dc.contributor.authorFranca, CT
dc.contributor.authorWhite, MT
dc.contributor.authorHe, W-Q
dc.contributor.authorHostetler, JB
dc.contributor.authorBrewster, J
dc.contributor.authorFrato, G
dc.contributor.authorMalhotra, I
dc.contributor.authorGruszczyk, J
dc.contributor.authorHuon, C
dc.contributor.authorLin, E
dc.contributor.authorKiniboro, B
dc.contributor.authorYadava, A
dc.contributor.authorSiba, P
dc.contributor.authorGalinski, MR
dc.contributor.authorHealer, J
dc.contributor.authorChitnis, C
dc.contributor.authorCowman, AF
dc.contributor.authorTakashima, E
dc.contributor.authorTsuboi, T
dc.contributor.authorTham, W-H
dc.contributor.authorFairhurst, RM
dc.contributor.authorRayner, JC
dc.contributor.authorKing, CL
dc.contributor.authorMueller, I
dc.date.accessioned2020-12-17T04:23:14Z
dc.date.available2020-12-17T04:23:14Z
dc.date.issued2017-09-26
dc.identifierpii: 28673
dc.identifier.citationFranca, C. T., White, M. T., He, W. -Q., Hostetler, J. B., Brewster, J., Frato, G., Malhotra, I., Gruszczyk, J., Huon, C., Lin, E., Kiniboro, B., Yadava, A., Siba, P., Galinski, M. R., Healer, J., Chitnis, C., Cowman, A. F., Takashima, E., Tsuboi, T. ,... Mueller, I. (2017). Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development. ELIFE, 6, https://doi.org/10.7554/eLife.28673.
dc.identifier.issn2050-084X
dc.identifier.urihttp://hdl.handle.net/11343/255286
dc.description.abstractThe study of antigenic targets of naturally-acquired immunity is essential to identify and prioritize antigens for further functional characterization. We measured total IgG antibodies to 38 P. vivax antigens, investigating their relationship with prospective risk of malaria in a cohort of 1-3 years old Papua New Guinean children. Using simulated annealing algorithms, the potential protective efficacy of antibodies to multiple antigen-combinations, and the antibody thresholds associated with protection were investigated for the first time. High antibody levels to multiple known and newly identified proteins were strongly associated with protection (IRR 0.44-0.74, p<0.001-0.041). Among five-antigen combinations with the strongest protective effect (>90%), EBP, DBPII, RBP1a, CyRPA, and PVX_081550 were most frequently identified; several of them requiring very low antibody levels to show a protective association. These data identify individual antigens that should be prioritized for further functional testing and establish a clear path to testing a multicomponent P. vivax vaccine.
dc.languageEnglish
dc.publisherELIFE SCIENCES PUBLICATIONS LTD
dc.titleIdentification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development
dc.typeJournal Article
dc.identifier.doi10.7554/eLife.28673
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleeLife
melbourne.source.volume6
dc.rights.licenseCC BY
melbourne.elementsid1248344
melbourne.contributor.authorHealer, Julie
melbourne.contributor.authorMueller, Ivo
melbourne.contributor.authorCowman, Alan
melbourne.contributor.authorTenorio Franca, Camila
melbourne.contributor.authorTham, Wai-Hong
dc.identifier.eissn2050-084X
melbourne.accessrightsOpen Access


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