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    Distinct cell-specific control of autoimmunity and infection by Fc gamma RIIb

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    Author
    Brownlie, RJ; Lawlor, KE; Niederer, HA; Cutler, AJ; Xiang, Z; Clatworthy, MR; Floto, RA; Greaves, DR; Lyons, PA; Smith, KGC
    Date
    2008-04-14
    Source Title
    Journal of Experimental Medicine
    Publisher
    ROCKEFELLER UNIV PRESS
    University of Melbourne Author/s
    Lawlor, Kathryn
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
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    Document Type
    Journal Article
    Citations
    Brownlie, R. J., Lawlor, K. E., Niederer, H. A., Cutler, A. J., Xiang, Z., Clatworthy, M. R., Floto, R. A., Greaves, D. R., Lyons, P. A. & Smith, K. G. C. (2008). Distinct cell-specific control of autoimmunity and infection by Fc gamma RIIb. JOURNAL OF EXPERIMENTAL MEDICINE, 205 (4), pp.883-895. https://doi.org/10.1084/jem.20072565.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255293
    DOI
    10.1084/jem.20072565
    Abstract
    FcgammaRIIb is an inhibitory Fc receptor expressed on B cells and myeloid cells. It is important in controlling responses to infection, and reduced expression or function predisposes to autoimmunity. To determine if increased expression of FcgammaRIIb can modulate these processes, we created transgenic mice overexpressing FcgammaRIIb on B cells or macrophages. Overexpression of FcgammaRIIb on B cells reduced the immunoglobulin G component of T-dependent immune responses, led to early resolution of collagen-induced arthritis (CIA), and reduced spontaneous systemic lupus erythematosus (SLE). In contrast, overexpression on macrophages had no effect on immune responses, CIA, or SLE but increased mortality after Streptococcus pneumoniae infection. These results help define the role of FcgammaRIIb in immune responses, demonstrate the contrasting roles played by FcgammaRIIb on B cells and macrophages in the control of infection and autoimmunity, and emphasize the therapeutic potential for modulation of FcgammaRIIb expression on B cells in inflammatory and autoimmune disease.

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