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dc.contributor.authorBrownlie, RJ
dc.contributor.authorLawlor, KE
dc.contributor.authorNiederer, HA
dc.contributor.authorCutler, AJ
dc.contributor.authorXiang, Z
dc.contributor.authorClatworthy, MR
dc.contributor.authorFloto, RA
dc.contributor.authorGreaves, DR
dc.contributor.authorLyons, PA
dc.contributor.authorSmith, KGC
dc.date.accessioned2020-12-17T04:24:10Z
dc.date.available2020-12-17T04:24:10Z
dc.date.issued2008-04-14
dc.identifierpii: jem.20072565
dc.identifier.citationBrownlie, R. J., Lawlor, K. E., Niederer, H. A., Cutler, A. J., Xiang, Z., Clatworthy, M. R., Floto, R. A., Greaves, D. R., Lyons, P. A. & Smith, K. G. C. (2008). Distinct cell-specific control of autoimmunity and infection by Fc gamma RIIb. JOURNAL OF EXPERIMENTAL MEDICINE, 205 (4), pp.883-895. https://doi.org/10.1084/jem.20072565.
dc.identifier.issn0022-1007
dc.identifier.urihttp://hdl.handle.net/11343/255293
dc.description.abstractFcgammaRIIb is an inhibitory Fc receptor expressed on B cells and myeloid cells. It is important in controlling responses to infection, and reduced expression or function predisposes to autoimmunity. To determine if increased expression of FcgammaRIIb can modulate these processes, we created transgenic mice overexpressing FcgammaRIIb on B cells or macrophages. Overexpression of FcgammaRIIb on B cells reduced the immunoglobulin G component of T-dependent immune responses, led to early resolution of collagen-induced arthritis (CIA), and reduced spontaneous systemic lupus erythematosus (SLE). In contrast, overexpression on macrophages had no effect on immune responses, CIA, or SLE but increased mortality after Streptococcus pneumoniae infection. These results help define the role of FcgammaRIIb in immune responses, demonstrate the contrasting roles played by FcgammaRIIb on B cells and macrophages in the control of infection and autoimmunity, and emphasize the therapeutic potential for modulation of FcgammaRIIb expression on B cells in inflammatory and autoimmune disease.
dc.languageEnglish
dc.publisherROCKEFELLER UNIV PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
dc.titleDistinct cell-specific control of autoimmunity and infection by Fc gamma RIIb
dc.typeJournal Article
dc.identifier.doi10.1084/jem.20072565
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleJournal of Experimental Medicine
melbourne.source.volume205
melbourne.source.issue4
melbourne.source.pages883-895
dc.rights.licenseCC BY-NC-SA
melbourne.elementsid1251371
melbourne.contributor.authorLawlor, Kathryn
dc.identifier.eissn1540-9538
melbourne.accessrightsOpen Access


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