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dc.contributor.authorSuwannatrai, K
dc.contributor.authorSuwannatrai, A
dc.contributor.authorTabsripair, P
dc.contributor.authorWelbat, JU
dc.contributor.authorTangkawattana, S
dc.contributor.authorCantacessi, C
dc.contributor.authorMulvenna, J
dc.contributor.authorTesana, S
dc.contributor.authorLoukas, A
dc.contributor.authorSotillo, J
dc.date.accessioned2020-12-17T04:25:01Z
dc.date.available2020-12-17T04:25:01Z
dc.date.issued2016-11-01
dc.identifierpii: PNTD-D-16-00996
dc.identifier.citationSuwannatrai, K., Suwannatrai, A., Tabsripair, P., Welbat, J. U., Tangkawattana, S., Cantacessi, C., Mulvenna, J., Tesana, S., Loukas, A. & Sotillo, J. (2016). Differential Protein Expression in the Hemolymph of Bithynia siamensis goniomphalos Infected with Opisthorchis viverrini. PLOS NEGLECTED TROPICAL DISEASES, 10 (11), https://doi.org/10.1371/journal.pntd.0005104.
dc.identifier.issn1935-2735
dc.identifier.urihttp://hdl.handle.net/11343/255299
dc.description.abstractBithynia siamensis goniomphalos is a freshwater snail that serves as the first intermediate host of the human liver fluke Opisthorchis viverrini. This parasite is a major public health problem in different countries throughout the Greater Mekong sub-region (Thailand, southern Vietnam, Lao PDR and Cambodia). Chronic O. viverrini infection also results in a gradual increase of fibrotic tissues in the biliary tract that are associated with hepatobiliary diseases and contribute to cholangiocarcinoma (a fatal type of bile duct cancer). Infectivity of the parasite in the snail host is strongly correlated with destruction of helminths by the snail's innate immune system, composed of cellular (hemocyte) and humoral (plasma) defense factors. To better understand this important host-parasite interface we applied sequential window acquisition of all theoretical spectra mass spectrometry (SWATH-MS) to identify and quantify the proteins from the hemolymph of B. siamensis goniomphalos experimentally infected with O. viverrini and compare them to non-infected snails (control group). A total of 362 and 242 proteins were identified in the hemocytes and plasma, respectively. Of these, 145 and 117 proteins exhibited significant differences in expression upon fluke infection in hemocytes and plasma, respectively. Among the proteins with significantly different expression patterns, we found proteins related to immune response (up-regulated in both hemocyte and plasma of infected snails) and proteins belonging to the structural and motor group (mostly down-regulated in hemocytes but up-regulated in plasma of infected snails). The proteins identified and quantified in this work will provide important information for the understanding of the factors involved in snail defense against O. viverrini and might facilitate the development of new strategies to control O. viverrini infection in endemic areas.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleDifferential Protein Expression in the Hemolymph of Bithynia siamensis goniomphalos Infected with Opisthorchis viverrini
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pntd.0005104
melbourne.affiliation.departmentVeterinary Biosciences
melbourne.source.titlePLoS Neglected Tropical Diseases
melbourne.source.volume10
melbourne.source.issue11
dc.rights.licenseCC BY
melbourne.elementsid1254340
melbourne.contributor.authorCantacessi, Cinzia
dc.identifier.eissn1935-2735
melbourne.accessrightsOpen Access


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