Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis.
AuthorWickramasinghe, A; Tulloch, AD; Hayes, RD; Chang, C-K; Broadbent, M; Di Forti, M; Murray, RM; Iyegbe, C; Stewart, R
Source TitleTranslational Psychiatry
PublisherSpringer Science and Business Media LLC
University of Melbourne Author/sMurray, Robin
Document TypeJournal Article
CitationsWickramasinghe, A., Tulloch, A. D., Hayes, R. D., Chang, C. -K., Broadbent, M., Di Forti, M., Murray, R. M., Iyegbe, C. & Stewart, R. (2015). Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis.. Transl Psychiatry, 5 (12), pp.e698-. https://doi.org/10.1038/tp.2015.198.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068593
We sought to test the hypothesis that the rs1344706 A allele will be associated with worse clinical outcome in first-episode psychosis. A data linkage was set up between a large systematic study of first-episode psychosis and an electronic health-record case register at the South London and Maudsley NHS Foundation Trust--a large provider of secondary mental-health care. A sample of 291 patients, who presented with a first psychotic episode (ICD10 diagnoses F20-29 or F30-33) and in whom the rs1344706 genotype had been assayed, were followed to examine the duration of mental-health in-patient care during the 2 years following first service contact, as a primary outcome. Secondary outcome measures were whether or not an in-patient episode occurred and the number of in-patient episodes during this period. A strong association was found between the number of rs1344706 A alleles and the cumulative duration of mental-health in-patient stay over the 2 years since initial presentation. In the 84.2% who experienced an in-patient episode during this period, the mean duration of admission was an additional 38 days for each A allele increment. Therefore, in addition to its potential role as a risk factor for psychosis, the ZNF804A rs1344706 A allele is associated with worse clinical outcome.
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