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dc.contributor.authorRigucci, S
dc.contributor.authorMarques, TR
dc.contributor.authorDi Forti, M
dc.contributor.authorTaylor, H
dc.contributor.authorDell'Acqua, F
dc.contributor.authorMondelli, V
dc.contributor.authorBonaccorso, S
dc.contributor.authorSimmons, A
dc.contributor.authorDavid, AS
dc.contributor.authorGirardi, P
dc.contributor.authorPariante, CM
dc.contributor.authorMurray, RM
dc.contributor.authorDazzan, P
dc.date.accessioned2020-12-17T04:25:26Z
dc.date.available2020-12-17T04:25:26Z
dc.date.issued2016-03
dc.identifierpii: S0033291715002342
dc.identifier.citationRigucci, S., Marques, T. R., Di Forti, M., Taylor, H., Dell'Acqua, F., Mondelli, V., Bonaccorso, S., Simmons, A., David, A. S., Girardi, P., Pariante, C. M., Murray, R. M. & Dazzan, P. (2016). Effect of high-potency cannabis on corpus callosum microstructure.. Psychol Med, 46 (4), pp.841-854. https://doi.org/10.1017/S0033291715002342.
dc.identifier.issn0033-2917
dc.identifier.urihttp://hdl.handle.net/11343/255302
dc.description.abstractBACKGROUND: The use of cannabis with higher Δ9-tetrahydrocannabinol content has been associated with greater risk, and earlier onset, of psychosis. However, the effect of cannabis potency on brain morphology has never been explored. Here, we investigated whether cannabis potency and pattern of use are associated with changes in corpus callosum (CC) microstructural organization, in patients with first-episode psychosis (FEP) and individuals without psychosis, cannabis users and non-users. METHOD: The CC of 56 FEP (37 cannabis users) and 43 individuals without psychosis (22 cannabis users) was virtually dissected and segmented using diffusion tensor imaging tractography. The diffusion index of fractional anisotropy, mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity was calculated for each segment. RESULTS: Across the whole sample, users of high-potency cannabis had higher total CC MD and higher total CC AD than both low-potency users and those who never used (p = 0.005 and p = 0.004, respectively). Daily users also had higher total CC MD and higher total CC AD than both occasional users and those who never used (p = 0.001 and p < 0.001, respectively). However, there was no effect of group (patient/individuals without psychosis) or group x potency interaction for either potency or frequency of use. The within-group analysis showed in fact that the effects of potency and frequency were similar in FEP users and in users without psychosis. CONCLUSIONS: Frequent use of high-potency cannabis is associated with disturbed callosal microstructural organization in individuals with and without psychosis. Since high-potency preparations are now replacing traditional herbal drugs in many European countries, raising awareness about the risks of high-potency cannabis is crucial.
dc.languageeng
dc.publisherCambridge University Press (CUP)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleEffect of high-potency cannabis on corpus callosum microstructure.
dc.typeJournal Article
dc.identifier.doi10.1017/S0033291715002342
melbourne.affiliation.departmentMedical Education
melbourne.source.titlePsychological Medicine
melbourne.source.volume46
melbourne.source.issue4
melbourne.source.pages841-854
dc.rights.licenseCC BY
melbourne.elementsid1334452
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754829
melbourne.contributor.authorMurray, Robin
dc.identifier.eissn1469-8978
melbourne.accessrightsOpen Access


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