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dc.contributor.authorReininghaus, U
dc.contributor.authorDutta, R
dc.contributor.authorDazzan, P
dc.contributor.authorDoody, GA
dc.contributor.authorFearon, P
dc.contributor.authorLappin, J
dc.contributor.authorHeslin, M
dc.contributor.authorOnyejiaka, A
dc.contributor.authorDonoghue, K
dc.contributor.authorLomas, B
dc.contributor.authorKirkbride, JB
dc.contributor.authorMurray, RM
dc.contributor.authorCroudace, T
dc.contributor.authorMorgan, C
dc.contributor.authorJones, PB
dc.date.accessioned2020-12-17T04:25:34Z
dc.date.available2020-12-17T04:25:34Z
dc.date.issued2015-05
dc.identifierpii: sbu138
dc.identifier.citationReininghaus, U., Dutta, R., Dazzan, P., Doody, G. A., Fearon, P., Lappin, J., Heslin, M., Onyejiaka, A., Donoghue, K., Lomas, B., Kirkbride, J. B., Murray, R. M., Croudace, T., Morgan, C. & Jones, P. B. (2015). Mortality in schizophrenia and other psychoses: a 10-year follow-up of the ӔSOP first-episode cohort.. Schizophr Bull, 41 (3), pp.664-673. https://doi.org/10.1093/schbul/sbu138.
dc.identifier.issn1787-9965
dc.identifier.urihttp://hdl.handle.net/11343/255303
dc.description.abstractThe excess mortality in people with psychotic disorders is a major public health concern, but little is known about the clinical and social risk factors which may predict this health inequality and help inform preventative strategies. We aimed to investigate mortality in a large epidemiologically characterized cohort of individuals with first-episode psychosis compared with the general population and to determine clinical and social risk factors for premature death. All 557 individuals with first-episode psychosis initially identified in 2 areas (Southeast London and Nottinghamshire, United Kingdom) were traced over a 10-year period in the ӔSOP-10 study. Compared with the general population, all-cause (standardized mortality ratio [SMR] 3.6, 95% confidence interval [CI] 2.6-4.9), natural-cause (SMR 1.7, 95% CI 1.0-2.7) and unnatural-cause (SMR 13.3, 95% CI 8.7-20.4) mortality was very high. Illicit drug use was associated with an increased risk of all-cause mortality (adj. rate ratio [RR] 2.31, 95% CI 1.06-5.03). Risk of natural-cause mortality increased with a longer time to first remission (adj. RR 6.61, 95% CI 1.33-32.77). Family involvement at first contact strongly reduced risk of unnatural-cause mortality (adj. RR 0.09, 95% CI 0.01-0.69). Our findings suggest that the mortality gap in people with psychotic disorders remains huge and may be wider for unnatural-cause mortality than previously reported. Efforts should now focus on further understanding and targeting these tractable clinical and social risk factors of excess mortality. Early intervention and dual diagnosis services may play a key role in achieving more rapid remission and carer involvement and addressing substance use problems to reduce excess mortality in psychosis.
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleMortality in schizophrenia and other psychoses: a 10-year follow-up of the ӔSOP first-episode cohort.
dc.typeJournal Article
dc.identifier.doi10.1093/schbul/sbu138
melbourne.affiliation.departmentMedical Education
melbourne.source.titleSchizophrenia Bulletin
melbourne.source.volume41
melbourne.source.issue3
melbourne.source.pages664-673
dc.rights.licenseCC BY
melbourne.elementsid1334475
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393685
melbourne.contributor.authorMurray, Robin
dc.identifier.eissn1745-1701
melbourne.accessrightsOpen Access


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