Interplay between childhood physical abuse and familial risk in the onset of psychotic disorders.

Download
Author
Fisher, HL; McGuffin, P; Boydell, J; Fearon, P; Craig, TK; Dazzan, P; Morgan, K; Doody, GA; Jones, PB; Leff, J; ...Date
2014-11Source Title
Schizophrenia BulletinPublisher
Oxford University Press (OUP)University of Melbourne Author/s
Murray, RobinAffiliation
Medical EducationMetadata
Show full item recordDocument Type
Journal ArticleCitations
Fisher, H. L., McGuffin, P., Boydell, J., Fearon, P., Craig, T. K., Dazzan, P., Morgan, K., Doody, G. A., Jones, P. B., Leff, J., Murray, R. M. & Morgan, C. (2014). Interplay between childhood physical abuse and familial risk in the onset of psychotic disorders.. Schizophr Bull, 40 (6), pp.1443-1451. https://doi.org/10.1093/schbul/sbt201.Access Status
Open AccessOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193698Abstract
BACKGROUND: Childhood abuse is considered one of the main environmental risk factors for the development of psychotic symptoms and disorders. However, this association could be due to genetic factors influencing exposure to such risky environments or increasing sensitivity to the detrimental impact of abuse. Therefore, using a large epidemiological case-control sample, we explored the interplay between a specific form of childhood abuse and family psychiatric history (a proxy for genetic risk) in the onset of psychosis. METHODS: Data were available on 172 first presentation psychosis cases and 246 geographically matched controls from the Aetiology and Ethnicity of Schizophrenia and Other Psychoses study. Information on childhood abuse was obtained retrospectively using the Childhood Experience of Care and Abuse Questionnaire and occurrence of psychotic and affective disorders in first degree relatives with the Family Interview for Genetic Studies. RESULTS: Parental psychosis was more common among psychosis cases than unaffected controls (adjusted OR = 5.96, 95% CI: 2.09-17.01, P = .001). Parental psychosis was also associated with physical abuse from mothers in both cases (OR = 3.64, 95% CI: 1.06-12.51, P = .040) and controls (OR = 10.93, 95% CI: 1.03-115.90, P = .047), indicative of a gene-environment correlation. Nevertheless, adjusting for parental psychosis did not measurably impact on the abuse-psychosis association (adjusted OR = 3.31, 95% CI: 1.22-8.95, P = .018). No interactions were found between familial liability and maternal physical abuse in determining psychosis caseness. CONCLUSIONS: This study found no evidence that familial risk accounts for associations between childhood physical abuse and psychotic disorder nor that it substantially increases the odds of psychosis among individuals reporting abuse.
Export Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References