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    ISCEV extended protocol for the photopic negative response (PhNR) of the full-field electroretinogram

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    Author
    Frishman, L; Sustar, M; Kremers, J; McAnany, JJ; Sarossy, M; Tzekov, R; Viswanathan, S
    Date
    2018-06-01
    Source Title
    Documenta Ophthalmologica
    Publisher
    SPRINGER
    University of Melbourne Author/s
    Sarossy, Marc
    Affiliation
    Ophthalmology (Eye & Ear Hospital)
    Metadata
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    Document Type
    Journal Article
    Citations
    Frishman, L., Sustar, M., Kremers, J., McAnany, J. J., Sarossy, M., Tzekov, R. & Viswanathan, S. (2018). ISCEV extended protocol for the photopic negative response (PhNR) of the full-field electroretinogram. DOCUMENTA OPHTHALMOLOGICA, 136 (3), pp.207-211. https://doi.org/10.1007/s10633-018-9638-x.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255329
    DOI
    10.1007/s10633-018-9638-x
    Abstract
    The International Society for Clinical Electrophysiology of Vision (ISCEV) Standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the ERG Standard, namely the photopic negative response (PhNR) of the light-adapted flash ERG, as a well-established technique that is broadly accepted by experts in the field. The PhNR is a slow negative-going wave after the b-wave that provides information about the function of retinal ganglion cells and their axons. The PhNR can be reduced in disorders that affect the innermost retina, including glaucoma and other forms of optic neuropathy. This document, based on existing literature, provides a protocol for recording and analyzing the PhNR in response to a brief flash. The protocol includes full-field stimulation, a frequency bandwidth of the recording in which the lower limit does not exceed 0.3 Hz, and a spectrally narrowband stimulus, specifically, a red flash on a rod saturating blue background. Suggested flash strengths cover a range up to and including the minimum required to elicit a maximum amplitude PhNR. This extended protocol for recording the PhNR provides a simple test of generalized retinal ganglion cell function that could be added to standard ERG testing.

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