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dc.contributor.authorUmapathysivam, MM
dc.contributor.authorLee, MY
dc.contributor.authorJones, KL
dc.contributor.authorAnnink, CE
dc.contributor.authorCousins, CE
dc.contributor.authorTrahair, LG
dc.contributor.authorRayner, CK
dc.contributor.authorChapman, MJ
dc.contributor.authorNauck, MA
dc.contributor.authorHorowitz, M
dc.contributor.authorDeane, AM
dc.date.accessioned2020-12-17T04:30:09Z
dc.date.available2020-12-17T04:30:09Z
dc.date.issued2014-02-01
dc.identifierpii: db13-0893
dc.identifier.citationUmapathysivam, M. M., Lee, M. Y., Jones, K. L., Annink, C. E., Cousins, C. E., Trahair, L. G., Rayner, C. K., Chapman, M. J., Nauck, M. A., Horowitz, M. & Deane, A. M. (2014). Comparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia. DIABETES, 63 (2), pp.785-790. https://doi.org/10.2337/db13-0893.
dc.identifier.issn0012-1797
dc.identifier.urihttp://hdl.handle.net/11343/255337
dc.description.abstractAcute administration of glucagon-like peptide 1 (GLP-1) and its agonists slows gastric emptying, which represents the major mechanism underlying their attenuation of postprandial glycemic excursions. However, this effect may diminish during prolonged use. We compared the effects of prolonged and intermittent stimulation of the GLP-1 receptor on gastric emptying and glycemia. Ten healthy men received intravenous saline (placebo) or GLP-1 (0.8 pmol/kg ⋅ min), as a continuous 24-h infusion ("prolonged"), two 4.5-h infusions separated by 20 h ("intermittent"), and a 4.5-h infusion ("acute") in a randomized, double-blind, crossover fashion. Gastric emptying of a radiolabeled mashed potato meal was measured using scintigraphy. Acute GLP-1 markedly slowed gastric emptying. The magnitude of the slowing was attenuated with prolonged but maintained with intermittent infusions. GLP-1 potently diminished postprandial glycemia during acute and intermittent regimens. These observations suggest that short-acting GLP-1 agonists may be superior to long-acting agonists when aiming specifically to reduce postprandial glycemic excursions in the treatment of type 2 diabetes.
dc.languageEnglish
dc.publisherAMER DIABETES ASSOC
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleComparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia
dc.typeJournal Article
dc.identifier.doi10.2337/db13-0893
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleDiabetes
melbourne.source.volume63
melbourne.source.issue2
melbourne.source.pages785-790
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1338265
melbourne.contributor.authorDeane, Adam
dc.identifier.eissn1939-327X
melbourne.accessrightsOpen Access


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