CRISPR-Cas systems: ushering in the new genome editing era
AuthorRojo, FP; Nyman, RKM; Johnson, AAT; Navarro, MP; Ryan, MH; Erskine, W; Kaur, P
PublisherTAYLOR & FRANCIS INC
University of Melbourne Author/sJohnson, Alexander
AffiliationSchool of BioSciences
Document TypeJournal Article
CitationsRojo, F. P., Nyman, R. K. M., Johnson, A. A. T., Navarro, M. P., Ryan, M. H., Erskine, W. & Kaur, P. (2018). CRISPR-Cas systems: ushering in the new genome editing era. BIOENGINEERED, 9 (1), pp.214-221. https://doi.org/10.1080/21655979.2018.1470720.
Access StatusOpen Access
In recent years there has been great progress with the implementation and utilization of Clustered Regularly Interspaced Palindromic Repeats (CRISPR) and CRISPR-associated protein (Cas) systems in the world of genetic engineering. Many forms of CRISPR-Cas9 have been developed as genome editing tools and techniques and, most recently, several non-genome editing CRISPR-Cas systems have emerged. Most of the CRISPR-Cas systems have been classified as either Class I or Class II and are further divided among several subtypes within each class. Research teams and companies are currently in dispute over patents for these CRISPR-Cas systems as numerous powerful applications are concurrently under development. This mini review summarizes the appearance of CRISPR-Cas systems with a focus on the predominant CRISPR-Cas9 system as well as the classifications and subtypes for CRISPR-Cas. Non-genome editing uses of CRISPR-Cas are also highlighted and a brief overview of the commercialization of CRISPR is provided.
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