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    Oxidative and endoplasmic reticulum stress in respiratory disease

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    Author
    Chen, AC-H; Burr, L; McGuckin, MA
    Date
    2018-06-13
    Source Title
    Clinical and Translational Immunology
    Publisher
    WILEY
    University of Melbourne Author/s
    McGuckin, Michael
    Affiliation
    Medicine Dentistry & Health Sciences
    Metadata
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    Document Type
    Journal Article
    Citations
    Chen, A. C. -H., Burr, L. & McGuckin, M. A. (2018). Oxidative and endoplasmic reticulum stress in respiratory disease. CLINICAL & TRANSLATIONAL IMMUNOLOGY, 7 (6), https://doi.org/10.1002/cti2.1019.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255351
    DOI
    10.1002/cti2.1019
    Abstract
    Oxidative stress and endoplasmic reticulum (ER) stress are related states that can occur in cells as part of normal physiology but occur frequently in diseases involving inflammation. In this article, we review recent findings relating to the role of oxidative and ER stress in the pathophysiology of acute and chronic nonmalignant diseases of the lung, including infections, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. We also explore the potential of drugs targeting oxidative and ER stress pathways to alleviate disease.

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