Oxidative and endoplasmic reticulum stress in respiratory disease
AuthorChen, AC-H; Burr, L; McGuckin, MA
Source TitleClinical and Translational Immunology
University of Melbourne Author/sMcGuckin, Michael
AffiliationMedicine Dentistry & Health Sciences
Document TypeJournal Article
CitationsChen, A. C. -H., Burr, L. & McGuckin, M. A. (2018). Oxidative and endoplasmic reticulum stress in respiratory disease. CLINICAL & TRANSLATIONAL IMMUNOLOGY, 7 (6), https://doi.org/10.1002/cti2.1019.
Access StatusOpen Access
Oxidative stress and endoplasmic reticulum (ER) stress are related states that can occur in cells as part of normal physiology but occur frequently in diseases involving inflammation. In this article, we review recent findings relating to the role of oxidative and ER stress in the pathophysiology of acute and chronic nonmalignant diseases of the lung, including infections, cystic fibrosis, idiopathic pulmonary fibrosis and asthma. We also explore the potential of drugs targeting oxidative and ER stress pathways to alleviate disease.
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