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    Could low birth weight and preterm birth be associated with significant burden of hip osteoarthritis? A systematic review

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    Author
    Hussain, SM; Ackerman, IN; Wang, Y; Zomer, E; Cicuttini, FM
    Date
    2018-06-08
    Source Title
    Arthritis Research and Therapy
    Publisher
    BMC
    University of Melbourne Author/s
    Ackerman, Ilana
    Affiliation
    Medicine and Radiology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Hussain, S. M., Ackerman, I. N., Wang, Y., Zomer, E. & Cicuttini, F. M. (2018). Could low birth weight and preterm birth be associated with significant burden of hip osteoarthritis? A systematic review. ARTHRITIS RESEARCH & THERAPY, 20 (1), https://doi.org/10.1186/s13075-018-1627-7.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255374
    DOI
    10.1186/s13075-018-1627-7
    Abstract
    BACKGROUND: Approaches for the prevention and treatment of hip osteoarthritis (OA) remain limited. There are recent data suggesting that low birth weight (LBW) and preterm birth may be risk factors for hip osteoarthritis. This has the potential to change the current paradigm of hip osteoarthritis prevention by targeting early life factors. The aim of this review was to examine the available evidence for an association of LBW and preterm birth with hip OA. The potential cost implications associated with total hip arthroplasty were also evaluated. METHODS: Ovid Medline, EMBASE, and Cinahl were searched up until August 2017 using MeSH terms and key words. Methodological quality was evaluated using the National Heart Lung and Blood Institute (NHLBI) quality assessment tool. Qualitative evidence synthesis was performed to summarise the results. Bradford Hill's criteria for causation including the temporal relationship, consistency, strength of the association, specificity, dose-response relationship, and analogy were used to assess the evidence for causation. Economic modelling was used to calculate the potential economic burden associated with LBW or preterm birth related total hip arthroplasty using Australian data from 2012 to 2015. RESULTS: Five studies, ranging from high to low quality, were included. Hip bone shape abnormalities examined included developmental hip dysplasia and immature hip, and hip osteoarthritis included osteophytes and total hip arthroplasty. A causal link between low birth weight or preterm birth and hip osteoarthritis was found. Of the 30,477 total hip arthroplasties performed for hip osteoarthritis in Australia in 2015, 5791 were estimated to be born preterm and 5273 with low birth weight. This equated to a potential total hip arthroplasty cost of AU$145,136,082 and AU$132,150,222 for these subgroups, respectively. CONCLUSION: Available data suggest that low birth weight and preterm birth are associated with hip bone shape abnormalities and hip osteoarthritis requiring total hip arthroplasty, with a substantial associated financial burden. Given the current lack of effective treatment and prevention strategies for hip osteoarthritis, this offers a new avenue for reducing the future burden of hip osteoarthritis.

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