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    Magnetic Nanoparticles Coated with a Thermosensitive Polymer with Hyperthermia Properties

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    Author
    Reyes-Ortega, F; Delgado, AV; Schneider, EK; Checa Fernandez, BL; Iglesias, GR
    Date
    2018-01-01
    Source Title
    Polymers
    Publisher
    MDPI
    University of Melbourne Author/s
    Schneider, Elena
    Affiliation
    Pharmacology and Therapeutics
    Metadata
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    Document Type
    Journal Article
    Citations
    Reyes-Ortega, F., Delgado, A. V., Schneider, E. K., Checa Fernandez, B. L. & Iglesias, G. R. (2018). Magnetic Nanoparticles Coated with a Thermosensitive Polymer with Hyperthermia Properties. POLYMERS, 10 (1), https://doi.org/10.3390/polym10010010.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255379
    DOI
    10.3390/polym10010010
    Abstract
    Magnetic nanoparticles (MNPs) have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by the enhanced permeability and retention effect. Their incorporation into biopolymer coatings enables the preparation of magnetic field-responsive, biocompatible nanoparticles that are well dispersed in aqueous media. Here we describe a synthetic route to prepare functionalized, stable magnetite nanoparticles (MNPs) coated with a temperature-responsive polymer, by means of the hydrothermal method combined with an oil/water (o/w) emulsion process. The effects of both pH and temperature on the electrophoretic mobility and surface charge of these MNPs are investigated. The magnetite/polymer composition of these systems is detected by Fourier Transform Infrared Spectroscopy (FTIR) and quantified by thermogravimetric analysis. The therapeutic possibilities of the designed nanostructures as effective heating agents for magnetic hyperthermia are demonstrated, and specific absorption rates as high as 150 W/g, with 20 mT magnetic field and 205 kHz frequency, are obtained. This magnetic heating response could provide a promising nanoparticle system for combined diagnostics and cancer therapy.

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