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dc.contributor.authorOtranto, D
dc.contributor.authorDantas-Torres, F
dc.contributor.authorde Caprariis, D
dc.contributor.authorDi Paola, G
dc.contributor.authorTarallo, VD
dc.contributor.authorLatrofa, MS
dc.contributor.authorLia, RP
dc.contributor.authorAnnoscia, G
dc.contributor.authorBreitshwerdt, EB
dc.contributor.authorCantacessi, C
dc.contributor.authorCapelli, G
dc.contributor.authorStanneck, D
dc.date.accessioned2020-12-17T04:37:54Z
dc.date.available2020-12-17T04:37:54Z
dc.date.issued2013-02-25
dc.identifierpii: PONE-D-12-34119
dc.identifier.citationOtranto, D., Dantas-Torres, F., de Caprariis, D., Di Paola, G., Tarallo, V. D., Latrofa, M. S., Lia, R. P., Annoscia, G., Breitshwerdt, E. B., Cantacessi, C., Capelli, G. & Stanneck, D. (2013). Prevention of Canine Leishmaniosis in a Hyper-Endemic Area Using a Combination of 10% Imidacloprid/4.5% Flumethrin. PLOS ONE, 8 (2), https://doi.org/10.1371/journal.pone.0056374.
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11343/255393
dc.description.abstractBACKGROUND: Dogs are the main reservoir hosts of Leishmania infantum, the agent of human zoonotic visceral leishmaniosis. This study investigated the efficacy of a polymer matrix collar containing a combination of 10% imidacloprid and 4.5% flumethrin as a novel prophylactic measure to prevent L. infantum infections in young dogs from a hyper-endemic area of southern Italy, with a view towards enhancing current control strategies against both human and canine leishmaniosis. METHODOLOGY/PRINCIPAL FINDINGS: The study was carried out on 124 young dogs, of which 63 were collared (Group A) while 61 were left untreated (Group B), from March-April 2011 until March 2012. Blood and skin samples were collected at baseline (April 2011) and at the first, second, third and fourth follow-up time points (July, September 2011 and November 2011, and March 2012, respectively). Bone marrow and conjunctiva were sampled at baseline and at the fourth follow-up. Serological, cytological and molecular tests were performed to detect the presence of L. infantum in the different tissues collected. At the end of the trial, no dog from Group A proved positive for L. infantum at any follow-up, whereas 22 dogs from Group B were infected (incidence density rate = 45.1%); therefore, the combination of 10% imidacloprid and 4.5% flumethrin was 100% efficacious for the prevention of L. infantum infection in young dogs prior to their first exposure to the parasite in a hyper-endemic area for CanL. CONCLUSIONS: The use of collars containing 10% imidacloprid and 4.5% flumethrin conferred long-term protection against infection by L. infantum to dogs located in a hyper-endemic area, thus representing a reliable and sustainable strategy to decrease the frequency and spread of this disease among the canine population which will ultimately result in the reduction of associated risks to human health.
dc.languageEnglish
dc.publisherPUBLIC LIBRARY SCIENCE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titlePrevention of Canine Leishmaniosis in a Hyper-Endemic Area Using a Combination of 10% Imidacloprid/4.5% Flumethrin
dc.typeJournal Article
dc.identifier.doi10.1371/journal.pone.0056374
melbourne.affiliation.departmentVeterinary Biosciences
melbourne.source.titlePLoS One
melbourne.source.volume8
melbourne.source.issue2
dc.rights.licenseCC BY
melbourne.elementsid1254366
melbourne.contributor.authorCantacessi, Cinzia
dc.identifier.eissn1932-6203
melbourne.accessrightsOpen Access


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