Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation
AuthorInfantino, S; Light, A; O'Donnell, K; Bryant, V; Avery, DT; Elliott, M; Tangye, SG; Belz, G; Mackay, F; Richard, S; ...
Source TitleNature Communications
PublisherNATURE PUBLISHING GROUP
University of Melbourne Author/sBelz, Gabrielle; Mackay, Fabienne; Infantino, Simona; Light, Amanda; Bryant, Vanessa
AffiliationMicrobiology and Immunology
Medical Biology (W.E.H.I.)
Document TypeJournal Article
CitationsInfantino, S., Light, A., O'Donnell, K., Bryant, V., Avery, D. T., Elliott, M., Tangye, S. G., Belz, G., Mackay, F., Richard, S. & Tarlinton, D. (2017). Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation. NATURE COMMUNICATIONS, 8 (1), https://doi.org/10.1038/s41467-017-01009-1.
Access StatusOpen Access
Arginine methylation catalyzed by protein arginine methyltransferases (PRMT) is a common post-translational modification in mammalian cells, regulating many important functions including cell signalling, proliferation and differentiation. Here we show the role of PRMT1 in B-cell activation and differentiation. PRMT1 expression and activity in human and mouse peripheral B cells increases in response to in vitro or in vivo activation. Deletion of the Prmt1 gene in mature B cells establishes that although the frequency and phenotype of peripheral B cell subsets seem unaffected, immune responses to T-cell-dependent and -independent antigens are substantially reduced. In vitro activation of Prmt1-deficient B cells with a variety of mitogens results in diminished proliferation, differentiation and survival, effects that are correlated with altered signal transduction from the B cell receptor. Thus PRMT1 activity in B cells is required for correct execution of multiple processes that in turn are necessary for humoral immunity.PRMT1 is an arginine methyltransferase involved in a variety of cell functions. Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and thereby for humoral immunity.
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