Show simple item record

dc.contributor.authorInfantino, S
dc.contributor.authorLight, A
dc.contributor.authorO'Donnell, K
dc.contributor.authorBryant, V
dc.contributor.authorAvery, DT
dc.contributor.authorElliott, M
dc.contributor.authorTangye, SG
dc.contributor.authorBelz, G
dc.contributor.authorMackay, F
dc.contributor.authorRichard, S
dc.contributor.authorTarlinton, D
dc.date.accessioned2020-12-17T04:39:05Z
dc.date.available2020-12-17T04:39:05Z
dc.date.issued2017-10-12
dc.identifierpii: 10.1038/s41467-017-01009-1
dc.identifier.citationInfantino, S., Light, A., O'Donnell, K., Bryant, V., Avery, D. T., Elliott, M., Tangye, S. G., Belz, G., Mackay, F., Richard, S. & Tarlinton, D. (2017). Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation. NATURE COMMUNICATIONS, 8 (1), https://doi.org/10.1038/s41467-017-01009-1.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/255401
dc.description.abstractArginine methylation catalyzed by protein arginine methyltransferases (PRMT) is a common post-translational modification in mammalian cells, regulating many important functions including cell signalling, proliferation and differentiation. Here we show the role of PRMT1 in B-cell activation and differentiation. PRMT1 expression and activity in human and mouse peripheral B cells increases in response to in vitro or in vivo activation. Deletion of the Prmt1 gene in mature B cells establishes that although the frequency and phenotype of peripheral B cell subsets seem unaffected, immune responses to T-cell-dependent and -independent antigens are substantially reduced. In vitro activation of Prmt1-deficient B cells with a variety of mitogens results in diminished proliferation, differentiation and survival, effects that are correlated with altered signal transduction from the B cell receptor. Thus PRMT1 activity in B cells is required for correct execution of multiple processes that in turn are necessary for humoral immunity.PRMT1 is an arginine methyltransferase involved in a variety of cell functions. Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and thereby for humoral immunity.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.titleArginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation
dc.typeJournal Article
dc.identifier.doi10.1038/s41467-017-01009-1
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleNature Communications
melbourne.source.volume8
melbourne.source.issue1
dc.rights.licenseCC BY
melbourne.elementsid1255843
melbourne.contributor.authorBelz, Gabrielle
melbourne.contributor.authorMackay, Fabienne
melbourne.contributor.authorInfantino, Simona
melbourne.contributor.authorLight, Amanda
melbourne.contributor.authorBryant, Vanessa
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record