Pattern Recognition Analysis Reveals Unique Contrast Sensitivity Isocontours Using Static Perimetry Thresholds Across the Visual Field
AuthorPhu, J; Khuu, SK; Nivison-Smith, L; Zangerl, B; Choi, AYJ; Jones, BW; Pfeiffer, RL; Marc, RE; Kalloniatis, M
Source TitleInvestigative Ophthalmology and Visual Science
PublisherASSOC RESEARCH VISION OPHTHALMOLOGY INC
University of Melbourne Author/sKalloniatis, Michael
AffiliationAnatomy and Neuroscience
Document TypeJournal Article
CitationsPhu, J., Khuu, S. K., Nivison-Smith, L., Zangerl, B., Choi, A. Y. J., Jones, B. W., Pfeiffer, R. L., Marc, R. E. & Kalloniatis, M. (2017). Pattern Recognition Analysis Reveals Unique Contrast Sensitivity Isocontours Using Static Perimetry Thresholds Across the Visual Field. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 58 (11), pp.4863-4876. https://doi.org/10.1167/iovs.17-22371.
Access StatusOpen Access
Purpose: To determine the locus of test locations that exhibit statistically similar age-related decline in sensitivity to light increments and age-corrected contrast sensitivity isocontours (CSIs) across the central visual field (VF). We compared these CSIs with test point clusters used by the Glaucoma Hemifield Test (GHT). Methods: Sixty healthy observers underwent testing on the Humphrey Field Analyzer 30-2 test grid using Goldmann (G) stimulus sizes I-V. Age-correction factors for GI-V were determined using linear regression analysis. Pattern recognition analysis was used to cluster test locations across the VF exhibiting equal age-related sensitivity decline (age-related CSIs), and points of equal age-corrected sensitivity (age-corrected CSIs) for GI-V. Results: There was a small but significant test size-dependent sensitivity decline with age, with smaller stimuli declining more rapidly. Age-related decline in sensitivity was more rapid in the periphery. A greater number of unique age-related CSIs was revealed when using smaller stimuli, particularly in the mid-periphery. Cluster analysis of age-corrected sensitivity thresholds revealed unique CSIs for GI-V, with smaller stimuli having a greater number of unique clusters. Zones examined by the GHT consisted of test locations that did not necessarily belong to the same CSI, particularly in the periphery. Conclusions: Cluster analysis reveals statistically significant groups of test locations within the 30-2 test grid exhibiting the same age-related decline. CSIs facilitate pooling of sensitivities to reduce the variability of individual test locations. These CSIs could guide future structure-function and alternate hemifield asymmetry analyses by comparing matched areas of similar sensitivity signatures.
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