Detection of adamantane-sensitive influenza A(H3N2) viruses in Australia, 2017: a cause for hope?

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    Author
    Hurt, A; Komadina, N; Deng, Y-M; Kaye, M; Sullivan, S; Subbarao, K; Barr, I
    Date
    2017-11-23
    Source Title
    Eurosurveillance
    Publisher
    EUR CENTRE DIS PREVENTION & CONTROL
    University of Melbourne Author/s
    Hurt, Aeron; Barr, Ian; Subbarao, Kanta; Sullivan, Sheena
    Affiliation
    Doherty Institute
    Melbourne School of Population and Global Health
    Microbiology and Immunology
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    Document Type
    Journal Article
    Citations
    Hurt, A., Komadina, N., Deng, Y. -M., Kaye, M., Sullivan, S., Subbarao, K. & Barr, I. (2017). Detection of adamantane-sensitive influenza A(H3N2) viruses in Australia, 2017: a cause for hope?. EUROSURVEILLANCE, 22 (47), pp.2-9. https://doi.org/10.2807/1560-7917.ES.2017.22.47.17-00731.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255426
    DOI
    10.2807/1560-7917.ES.2017.22.47.17-00731
    Abstract
    For over a decade virtually all A(H3N2) influenza viruses have been resistant to the adamantane class of antivirals. However, during the 2017 influenza season in Australia, 15/461 (3.3%) adamantane-sensitive A(H3N2) viruses encoding serine at residue 31 of the M2 protein were detected, more than the total number identified globally during the last 6 years. A return to wide circulation of adamantane-sensitive A(H3N2) viruses would revive the option of using these drugs for treatment and prophylaxis.

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