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    Isolated Horizontal Gaze palsy: observations and explanations

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    Author
    Ewe, R; White, OB; Burke, A
    Date
    2017-11-15
    Source Title
    Frontiers in Neurology
    Publisher
    FRONTIERS MEDIA SA
    University of Melbourne Author/s
    White, Owen
    Affiliation
    Medicine and Radiology
    Metadata
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    Document Type
    Journal Article
    Citations
    Ewe, R., White, O. B. & Burke, A. (2017). Isolated Horizontal Gaze palsy: observations and explanations. FRONTIERS IN NEUROLOGY, 8 (NOV), https://doi.org/10.3389/fneur.2017.00611.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/255437
    DOI
    10.3389/fneur.2017.00611
    Abstract
    We present three cases that we suggest require a novel diagnosis and a reconsideration of current understandings of pontine anatomy. In this case series, we highlight a series of patients with monophasic, fully recovering inflammatory lesions in the pontine tegmentum not due to any of the currently recognized causes of this syndrome. We highlight other similar cases in the literature and suggest there may be a particular epitope for an as-yet-undiscovered antibody underlying the tropism for this area. We highlight the potential harm of misdiagnosis with relapsing inflammatory or other serious diagnoses with significant adverse impact on the patient. In addition, we propose that this would support a reinterpretation of the currently accepted anatomy of the pontine gaze inputs to the median longitudinal fasciculus and paramedian pontine reticular formation.

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