Show simple item record

dc.contributor.authorBivard, A
dc.contributor.authorLincz, LF
dc.contributor.authorMaquire, J
dc.contributor.authorParsons, M
dc.contributor.authorLevi, C
dc.date.accessioned2020-12-18T02:41:54Z
dc.date.available2020-12-18T02:41:54Z
dc.date.issued2017-03-01
dc.identifierpii: ACN3392
dc.identifier.citationBivard, A., Lincz, L. F., Maquire, J., Parsons, M. & Levi, C. (2017). Platelet microparticles: a biomarker for recanalization in rtPA-treated ischemic stroke patients. ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 4 (3), pp.175-179. https://doi.org/10.1002/acn3.392.
dc.identifier.issn2328-9503
dc.identifier.urihttp://hdl.handle.net/11343/255459
dc.description.abstractOBJECTIVES: Identification of a biomarker for acute recanalization could have significant clinical impact. METHODS: We prospectively collected baseline, 24-h, and 90-day clinical and imaging data from consecutive ischemic stroke patients who fulfilled standard clinical eligibility criteria for treatment with intravenous recombinant tissue plasminogen activator (rtPA). Computed tomography angiography was acquired at 24 h and assessed using the thrombolysis is myocardial infarction (TIMI) scale with a score of 2b/3 indicating recanalization. Blood samples collected at 24 h after stroke symptom onset were used to measure the inflammatory biomarkers of glycoprotein IIb (CD41) expressing microparticles (MP), C-reactive protein (CRP), COX 2, APOE, and Angiopoietin 1. Analysis was performed using linear regression and Pearson's correlation coefficient. RESULTS: A total of 57 patients met study eligibility criteria and had sufficient data and sample quality to be analyzed. Circulating levels of platelet derived CD41 + MP were significantly related to reperfusion (Pearson correlation, PC: 0.554, P < 0.001) and recanalization (PC: 0.495, P < 0.001) as well as related with 3-month modified Rankin Score (PC: 0.483, P < 0.001). CRP was significantly negatively correlated with recanalization on 24 h CTA (PC: -0.292, P = 0.041). Backward logistic regression with CRP and CD41 + MP increased the association with reperfusion (r2 = 0.357 P < 0.001). INTERPRETATION: There is a significant relationship between the inflammatory biomarkers CD41 + MP and CRP and recanalization.
dc.languageEnglish
dc.publisherWILEY
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titlePlatelet microparticles: a biomarker for recanalization in rtPA-treated ischemic stroke patients
dc.typeJournal Article
dc.identifier.doi10.1002/acn3.392
melbourne.affiliation.departmentMedicine (RMH)
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleAnnals of Clinical and Translational Neurology
melbourne.source.volume4
melbourne.source.issue3
melbourne.source.pages175-179
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1286104
melbourne.contributor.authorBivard, Andrew
melbourne.contributor.authorParsons, Mark
dc.identifier.eissn2328-9503
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record